中国组织工程研究Issue(45)：7348-7352,5.DOI:10.3969/j.issn.2095-4344.2014.45.024
干细胞移植改善骨量：研究进展与应用前景
Stem cell transplantation improves bone mass:research progress and application prospects
曹德宇 1李锋 1齐宝昶 1顾群 1王春利 1陶树清1
作者信息
- 1. 哈尔滨医科大学附属第二医院骨二科，黑龙江省哈尔滨市 150001
- 折叠
摘要
Abstract
BACKGROUND:Studies have shown that bone loss can lead to a series of diseases, such as osteoporotic fractures, thus seeking to increase bone mass has become a goal of the majority of researchers. <br> OBJECTIVE:To summarize the current studies of improving bone mass by using stem cel transplantation, hoping to the extensive application of stem cel transplantation in the clinical treatment of osteoporosis as early as possible. <br> METHODS:A computer-based search of PubMed and CNKI was performed by the first author to retrieve articles relevant to stem cel therapy for osteoporosis published from January 1997 to October 2014. The keywords were“to improve bone mass, regenerative medicine, bone marrow mesenchymal stem cel transplantation, stem cel therapy”in Chinese and English, respectively, which appeared in the title, abstract or keywords. Articles published recently or in authoritative journals were preferred, and final y 28 articles were included in result analysis. <br> RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cel s which are isolated and cultured easily can proliferate rapidly and have multi-lineage differentiation potential. Studies have shown that the osteogenic differentiation of bone marrow mesenchymal stem cel s can real y improve bone mass, and obtain more achievements in the treatment of orthopedic disorders. This new cel therapy can help to accelerate bone healing and reduce treatment time, offering a new therapeutic choice for orthopedic surgery, plastic surgery, oral and maxil ofacial surgery, and therefore, it has broad application prospects.关键词
干细胞/移植/骨髓间充质干细胞/改善骨量/再生医学/干细胞移植/干细胞治疗Key words
bone marrow/mesenchymal stem cel s/platelet-rich plasma/osteoporosis分类
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曹德宇,李锋,齐宝昶,顾群,王春利,陶树清..干细胞移植改善骨量：研究进展与应用前景[J].中国组织工程研究,2014,(45):7348-7352,5.
