中国组织工程研究Issue(45)：7370-7374,5.DOI:10.3969/j.issn.2095-4344.2014.45.028
骨髓间充质干细胞与人脐静脉内皮细胞的共培养
Coculture of human umbilical vein endothelial cells and bone marrow mesenchymal stem cells
罗淑平 1杜玉婷 2白驹2
作者信息
- 1. 解放军兰州军区兰州总医院重症医学科，甘肃省兰州市 730050
- 2. 成都市亚非牙科，四川省成都市 610000
- 折叠
摘要
Abstract
BACKGROUND:Coculture of bone marrow mesenchymal stem cel s and human umbilical vein endothelial cel s can improve both osteogenic and angiogenic outcomes and provide a promising strategy for bone tissue engineering and osteanagenesis. <br> OBJECTIVE:To summarize recent researches and related progresses in coculture of human umbilical vein endothelial cel s and bone marrow mesenchymal stem cel s. <br> METHODS:A computer-based online search of CNKI database from January 2000 to March 2012, PubMed database and Web of Knowledge database from January 1980 to March 2012, was performed with the keywords of“human umbilical vein endothelial cel s, bone mesenchymal stem cel s, coculture, tissue engineering”both in Chinese and English. A total of 135 articles were screened out, 103 of them were excluded due to unrelated study objective and repeated contents, and final y 32 articles were involved in further analysis. <br> RESULTS AND CONCLUSION:At present, studies on coculture of bone marrow mesenchymal stem cel s and human umbilical vein endothelial cel s mainly focus on mimicking in vivo environments, the interactions between cel s, and the influence of different cel ratios and culture media. Most of these researches play important roles in bone tissue engineering and bone regeneration therapy, but the mechanism of action and concrete regulation in <br> vivo between bone marrow mesenchymal stem cel s and human umbilical vein endothelial cel s stil need further research and analysis.关键词
干细胞/移植/人脐静脉内皮细胞/骨髓间充质干细胞/共培养/成血管作用/成骨作用Key words
umbilical veins/endothelial cel s/bone marrow/mesenchymal stem cel s/coculture techniques分类
医药卫生引用本文复制引用
罗淑平,杜玉婷,白驹..骨髓间充质干细胞与人脐静脉内皮细胞的共培养[J].中国组织工程研究,2014,(45):7370-7374,5.
