中国组织工程研究Issue(49)：7990-7994,5.DOI:10.3969/j.issn.2095-4344.2014.49.021
回肠代膀胱家兔模型制作中不同的麻醉药物
Anesthetics in establishment of rabbit models of ileal neobladder
沈俭 1黄春霞 2余云兰 2刘洪新 1程志军2
作者信息
- 1. 上海交通大学医学院附属新华医院崇明分院 泌尿科，上海市 202150
- 2. 上海交通大学医学院附属新华医院崇明分院 麻醉科，上海市 202150
- 折叠
摘要
Abstract
BACKGROUND:The anesthesia process is required strict in establishing rabbit models of ileal neobladder. It is required for cleaning operation field, quick postoperative recovery, and the choice of anesthetics and anesthesia does not influence smooth muscle peristalsis. OBJECTIVE:To compare the anesthetic effects between urethane and chloral hydrate in rabbits with ileal neobladder. METHODS:Eighteen rabbits were randomly assigned to urethane and chloral hydrate groups, and were respectively anesthetized with 20% urethane 5 mL/kg and 10% chloral hydrate 2 mL/kg through the ear vein. Double ureter was dissociated at 1 cm outside original bladder, and 15 cm-intestine obtained from 10 cm of ileocecal junction was implanted so as to establish models of ileal neobladder. RESULTS AND CONCLUSION:Heart rates were significantly lower compared with these before anesthesia in al cases (P≤ 0.05), but no differences were detected between two groups (P > 0.05). Compared with the chloral hydrate group, the maintain time and recovery time were longer and the mortality rate was higher in the urethane group. Above data indicated that chloral hydrate is a safe long-acting anesthetic in establishing rabbit models of ileal neobladder.关键词
实验动物/组织工程/回肠代膀胱/动物模型/麻醉/水合氯醛/乌拉坦/围术期/麻醉剂Key words
ileum/urinary bladder/anesthesia/anesthetics分类
医药卫生引用本文复制引用
沈俭,黄春霞,余云兰,刘洪新,程志军..回肠代膀胱家兔模型制作中不同的麻醉药物[J].中国组织工程研究,2014,(49):7990-7994,5.
