中国组织工程研究Issue(24)：3894-3898,5.DOI:10.3969/j.issn.2095-4344.2015.24.023
OPG-RANKL-RANK信号系统是调节破骨细胞及骨质疏松症的重要途径
OPG-RANKL-RANK signaling system is an important approach to regulate osteoclasts and osteoporosis
摘要
Abstract
BACKGROUND:The OPG-RANKL-RANK transport system plays a crucial role in bone resorption mechanism of osteoclasts. OBJECTIVE:To observe the expression of OPG-RANKL-RANK signaling system in osteoclasts, osteoporosis, and the targeted therapy of OPG-RANKL-RANK signaling system. METHODS:We retrieved related literatures in the periodicals database with the key words of“osteoprotegerin, RANKL, RANK, osteoclasts, osteoporosis”in English and Chinese. According to the inclusion criteria, the literatures were included in this study after the evaluation of quality. RESULTS AND CONCLUSION:The mature of osteoclasts is mediated via OPG-RANKL-RANK signaling system and its associated signaling pathways. This signal pathway leads to the mechanism of osteoporosis. At the genetic and molecular levels, the targeted therapy of osteoporosis has become the focus. OPG-RANKL-RANK signaling system can provide a research platform for targeted treatment of osteoporosis, and OPG-RANKL-RANK signaling system is an important way to the regulation of osteoclasts and osteoporosis.关键词
组织构建/骨组织工程/骨质疏松症/OPG-RANKL-RANK信号系统/破骨细胞/国家自然科学基金Key words
Osteoporosis/RANK Ligand/Osteoprotegerin/Osteoclasts分类
医药卫生引用本文复制引用
黎彦龙,何明,陈秉雄,陈秉虎,王君霞,王天学,韦宏,宋敏..OPG-RANKL-RANK信号系统是调节破骨细胞及骨质疏松症的重要途径[J].中国组织工程研究,2015,(24):3894-3898,5.基金项目
国家自然科学基金(81360554)；甘肃省省青年科技基金计划(1208RJYA066) （81360554）
