现代医院Issue(8)：9-10,13,3.DOI:10.3969/j.issn.1671-332X.2014.08.003
石棉暴露下内质网应激在肺泡上皮细胞凋亡中的作用机制
THE MECHANISM OF ENDOPLASMIC RETICULUM STRESS INDUCING ALVEOLAR EPI-THELIAL CELLS APOPTOSIS UNDERLYING ASBESTOS EXPOSURE
摘要
Abstract
Objective To investigate the role of endoplasmic reticulum stress ( ERS) in asbestos-induced Alveolar epithelial cell apoptosis.Methods A549 cells were treated with asbestos to observe the expression of ERS proteins and apop-tosis gene by immunofluorescence staining and western blotting.Results Under asbestos exposure, the expression of Bip, GRP94, IRE-1α, BAX and BAK are up-regulated.There is a positive correlativity of the expression of proteins to the ex-posure time of asbestos.Conclusion Endoplasmic reticulum stress takes part in asbestos-induced apoptosis.关键词
石棉/内质网应激/凋亡Key words
Asbestos/Endoplasmic Reticulum Stress/Apoptosis引用本文复制引用
周煦,刘刚..石棉暴露下内质网应激在肺泡上皮细胞凋亡中的作用机制[J].现代医院,2014,(8):9-10,13,3.基金项目
国家自然科学基金（编号81172615），广东省自然科学基金（编号S2012010008299），广东医学院青年基金项目 （）
