现代医院Issue(8)：71-72,2.DOI:10.3969/j.issn.1671-332X.2014.08.029
脐血血红蛋白电泳 Hb A值辅助诊断胎儿β-地中海贫血及鉴定母血污染的价值
THE HB A OF HEMOGLOBIN ELECTROPHORESIS IN PRENATAL CORD BLOOD PRE-DICTING FORβ-THALASSEMIA AND MATERNAL CELL CONTAMINATION
郭浩 1郭莉 1唐斌 1杜丽 1骆明勇 1秦丹卿 1王奕霞 1王继成1
作者信息
- 1. 广东省妇幼保健院 广东广州 511400
- 折叠
摘要
Abstract
Objective To investigate the performance of Hb A in the prediction of prenatal diagnosising of foetal β-thalassemia and the application of hemoglobin electrophoresis in the second and third trimester of gestation in detecting for ma-ternal blood pollution.Methods In 54 cases there were prior screening for β-globin defects by High risk pregnancies ofβ-thalassemia.The core blood samples which were collecting in the second and third trimester of gestation ( between 24~28 w) were performed for the prenatal diagnosis with Hemoglobin electrophoresis and genetic testing.Results The Hb A in 12 normal cases and 31 mild β-thalassemia cases were observed in (6.3%±1.9%) and 2.6%~3.7%, respectively.10 cases of β0 -thalassemia included Hb A were 0 (n=6), Hb A were 0.4%~0.7% (n=4).Besides, one case were sus-pected as maternal cell contamination.Conclusion The Hb A of hemoglobin electrophoresis was an effective marker to pre-dict the β0 -thalassemia, mild β-thalassemia and β-thalassemia intermedia for fetuses.This study has also confirmed that hemoglobin electrophoresis was definitely helpful in detecting for maternal cell contamination.关键词
脐血/血红蛋白电泳/产前诊断/β地中海贫血/母血污染Key words
Cord blood/Hemoglobin electrophoresis/Prenatal diagnosis/β-thalassemia/Maternal cell contamina-tion引用本文复制引用
郭浩,郭莉,唐斌,杜丽,骆明勇,秦丹卿,王奕霞,王继成..脐血血红蛋白电泳 Hb A值辅助诊断胎儿β-地中海贫血及鉴定母血污染的价值[J].现代医院,2014,(8):71-72,2.
