现代医院Issue(1)：23-26,4.DOI:10.3969/j.issn.1671-332X.2015.01.006
脑钠肽基因多态性与先天性心脏病易感性的相关性研究
ASSOCIATION OF GENETIC POLYMORPHISM IN BRAIN NATRIURETIC PEPTIDE GENE ANDTHE SUSCEPTIBILITY OF CONGENITAL HEART DISEASES
摘要
Abstract
Objective To study the correlation between brain natriuretic peptide ( NPPB) SNP genes (rs198389 and rs198388) and the susceptibility of congenital heart diseases in the population of Boluo County. Methods NPPB gene SNP locus (rs198389 and rs198388) genotypes of 30 cases of congenital heart diseases and the normal control group with 30 cases were detected with multiple SNaPshot technique.Results The distribution frequencies of 3 genotypes of AA, AG and GG in rs198389 locus of NPPB gene in the CHD group were 43.3%, 36.7% and 20%, which had a significant difference compared with the control group (p <0.05).AG and GG geno-types increased the onset risk of congenital heart disease (OR =3.76, 95%CI =2.14 ~5.02; OR =2.25, 95%CI =1.05 ~3.34).The distribution frequencies of AA and GG genotypes in rs198388 locus of NPPB gene in the CHD group were 20% and 63.3%, which had a significant difference compared with the control group (p <0.05).GG genotype increased the onset risk of congenital heart disease(OR =5.68, 95%; CI =4.86 ~7.05).Conclusion In the population of Boluo County, brain natriuretic peptide (NPPB) SNP genes (rs198389 and rs198388) can be asso-ciated with congenital heart diseases.关键词
脑钠肽基因/单核苷酸多态性/先天性心脏病遗传易感性Key words
Brain natriuretic peptide(BNP)/Single nucleotide polymorphism (SNP)/Congenital heart disease (CHD)/Genetic susceptibility引用本文复制引用
陈惠英,李连欢,钟丽云,刘锦光..脑钠肽基因多态性与先天性心脏病易感性的相关性研究[J].现代医院,2015,(1):23-26,4.基金项目
惠州市科技计划项目 （）
