现代医院2015，Vol.15Issue(5)：37-39,3.DOI:10.3969/j.issn.1671-332X.2015.05.013
葡萄糖再灌注对2型糖尿病并发低血糖患者影响的研究
THE EFFECT OF GLUCOSE REPERFUSION ON TYPE 2 DIABETES MELLITUS COMPLI-CATED WITH HYPOGLYCEMIA
摘要
Abstract
Objective To observe the changes of biochemical indexes of type 2 diabetic patients with hypoglycemia after rising glucose to different levels, and to investigate the effects and its mechanism of glucose reperfusion.Methods 60 cases of patients with type 2 diabetes mellitus complicated with moderate to severe hypoglycemia in our hospital were randomly divided into group A and B with 30 cases in each.Fingertip blood glucose were in-creased to 6~8 mmol/L and 9~12 mmol/L;35 cases of type 2 diabetic patients with fingertip blood glucose at 6~12 mmol/L were randomly selected as the control group ( group C) .There were no statistically significant differences at age, AST, BUN and Cr between the groups.The baseline glucose, CK, CK-MB, CysC and CRP of groups A and B had no significant difference.The changes of biochemical glycemic index and CRP of group A and B were then compared.Results CK and CK-MB of group A decreased significantly after rising glucose (p<0.05), CK and CK-MB of group B increased significantly after rising glucose compared with group A ( p<0.05);CK and CK-MB of group C decreased significantly compared with group A and B before rising glucose (p<0.05);CysC and CRP of group A had no significant difference before and after rising glucose ( P>0.05) , CysC and CRP of group B increased significantly after rising glucose and compared with group A (p<0.05);CysC and CRP of group C decreased signifi-cantly compared with group B after rising glucose (p<0.05).CRP and blood glucose (r=0.395, p<0.01), CysC ( r=0.365, p<0.01) of the three groups were positively correlated.Conclusion The relatively high level of glucose in type 2 diabetic patients with hypoglycemia is not conducive to cardiac repair, and may lead to early renal dam-age, suggesting the presence of glucose reperfusion injury;CRP relates with glucose reperfusion injury.关键词
糖尿病/低血糖/葡萄糖再灌注Key words
Diabetes mellitus/Hypoglycemia/Glucose reperfusion引用本文复制引用
刘雪芳,夏碧文,曾炼坤,蒋婵,周晓华..葡萄糖再灌注对2型糖尿病并发低血糖患者影响的研究[J].现代医院,2015,15(5):37-39,3.基金项目
增城市人民医院青年医学人才培育基金(编号:2013-QN-002) （编号:2013-QN-002）
