现代医院2015，Vol.15Issue(5)：74-76,78,4.DOI:10.3969/j.issn.1671-332X.2015.05.028
不同蓝光及照射方式治疗新生儿高胆红素血症临床分析
TREATMENT OF NEONATAL HYPERBILIRUBINEMIA BY DIFFERENT METHODS OF BLUE-LIGHT IRRADIATION
吴少伟 1潘学军1
作者信息
- 1. 佛山市南海区第五人民医院 广东佛山 528231
- 折叠
摘要
Abstract
Objective To study the clinical efficacy and adverse reactions of different blue-light and expo-sure patterns for the treatment of neonatal hyperbilirubinemia.Methods 127 neonates with hyperbilirubinemia were divided into cold-light illuminator blue-light irradiation group (group A, n=32), cold-light illuminator blue-light group intermittent irradiation group (group B, n=32), traditional blue-light irradiation group (group C, n=31) and traditional blue-light intermittent irradiation group (group D, n=32).The treatment course of the four groups was all 72 hours.The level of serum total bilirubin ( TBIL) , direct bilirubin ( DBIL) and auditory brainstem response before and after treatment in the four groups were respectively observed and compared.The adverse reactions associated with treatment were recorded and compared among the four groups.After 9 months of follow-up, the audi-tory brainstem response ( ABR) was respectively tested at 3 days, 3 months and 9 months after the treatment.Results The level of TBIL in the four groups after treatment were significantly decreased compared with that before treatment (p<0.01), and the level of TBIL in cold-light illuminator blue-light group was significantly decreased compared with that in traditional blue-light group ( p<0.05 ) .The total effectiveness in cold-light illuminator blue-light group was significantly higher than that in traditional blue-light group ( p<0.05) .The incidence of adverse reaction in cold-light illuminator blue-light group was significantly lower than that in traditional blue-light group ( p<0.01), and the incidence of adverse reaction in group C was significantly higher than that in group D (p<0.05).At day 3 after treatment, the abnormal rates of ABR in the cold-light illuminator blue-light group was significantly lower than that in the traditional blue-light group (p<0.05).After 3 months of treatment, the abnormal rates of ABR was insignificantly different among the four groups (p>0.05).The ABR in the four groups returned to the nor-mal after 9 months of treatment.Conclusion The therapy of the cold-light illuminator blue-light irradiation has significant clinical efficacy in the treatment of neonatal hyperbilirubinemia.It can effectively reduce the hearing im-pairment of neonates, and the incidence of adverse reaction and total effective rates are equivalent in therapeutic pat-terns of intermittent irradiation and continuous irradiation.关键词
新生儿高胆红素血症/冷光源蓝光/传统蓝光/照射方式/听性脑干反应Key words
Neonatal hyperbilirubinemia/Cold-light illuminator blue-light/Traditional blue-light/Ex-posure patterns/Auditory brainstem response引用本文复制引用
吴少伟,潘学军..不同蓝光及照射方式治疗新生儿高胆红素血症临床分析[J].现代医院,2015,15(5):74-76,78,4.
