现代医院Issue(6)：17-19,3.DOI:10.3969/j.issn.1671-332X.2015.06.007
PTEN 和 P27蛋白的表达在食管上皮增生和癌变过程中的意义
THE SIGNIFICANCE OF EXPRESSION OF PTEN AND P27 PROTEINS IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS
陈杰生 1吴名耀2
作者信息
- 1. 汕头市澄海区人民医院 广东汕头 515800
- 2. 汕头大学医学院病理学教研室 广东汕头 515041
- 折叠
摘要
Abstract
Objective To investigate the expression of PTEN and P 27 proteins in esophageal epitheliosis and carcinogenesis , and the relation to the development of esophageal carcinoma .Methods PTEN and P27 proteins ex-pression in 60 fresh tissue specimens , including esophageal mucosa above the upper surgical margin , carcinoma in si-tu and mucosa adjacent to tumor , were detected using immunohistochemical method .Results The expression of e-sophageal epithelial cells PTEN and P 27 proteins in normal , hyperplastic and malignant gradually decreased , which showed a similar distribution pattern in esophageal carcinogenesis .Conclusion Malignant transformation expression change of PTEN and P 27 proteins and esophageal mucosa are closely related , and the expression of PTEN and P 27 proteins deletion may be a biological marker useful and esophageal cancer early diagnosis index .关键词
PTEN/P27/食管上皮/癌变过程Key words
PTEN/P27/Esophageal epithelium/Carcinogenesis引用本文复制引用
陈杰生,吴名耀..PTEN 和 P27蛋白的表达在食管上皮增生和癌变过程中的意义[J].现代医院,2015,(6):17-19,3.
