现代医院Issue(7)：18-20,3.DOI:10.3969/j.issn.1671-332X.2015.07.007
不同剂量右美托咪定应用于剖宫产术中预防卡前列素氨丁三醇不良反应的对比研究
EFFECT OF DIFFERENT CONCENTRATIONS OF DEXMEDETOMIDINE ON ADVERSE EF-FECTS INDUCED BY CARBOPROST TROMETHAMINE DURING CESAREAN DELIVERY
摘要
Abstract
Objective To investigate and compare the inhibitory effect of different concentrations of dexme -detomidine on adverse effects induced by Carboprost Tromethamine during cesarean delivery .Methods Ninety women ASA status I and II in Labor who requested epidural analgesia were randomly allocated to three groups :1 ) control group(saline infusion);2)low cencentration of dexmedetomidine (0.3 μg・ kg/h);3)high cencentration of dexmedetomidine (0.6 μg・ kg/h).The control group was given saline injection until the end of the operation .The dexmedetomidine group was given dexmedetomidine injection of 1 μg/kg,and following with continuous intravenous injection of dexmedetomidine by 0.3μg・ kg/h or 0.6μg・ kg/h.The operation time,fluid complementation volume , bleeding volume , MAP,HR,RR, SPO2 and Ramsay score in three designed groups were monitored .Adverse reaction like nausea,vomiting,flush and headache , chest and abdominal pain were recorded .Results There was no differ-ence in the operation time ,fluid complementation volume , bleeding volume between three groups .There was no sig-nificant difference in RR,SpO2,scores of Ramsay at each different point of time between three groups , while the MAP and HR in 0.3 μg・ kg/h or 0.6 μg・ kg/h dexmedetomidine at T2 and T3 was reduced compared with saline infu-sion group.In comparison with control group , low and high cencentrations of dexmedetomidine markedly reduced ad-verse effect induced by Carboprost Tromethamine .Futhermore, there was significant difference in suppressing the Carboprost Tromethamine induced adverse effect between pre -infusion with low concentration and high concentration of dexmedetomidine .Conclusion Dexmedetomidine effectively reduce the hemodynamic fluctuations and adverse re -actions induced by carboprost tromethamine in cesarean section .Dexmedetomidine infusion speed of 0.6 μg・ kg/h was preferential to be recommend to reduce related adverse reactions in comparison with the speed of 0.3μg・ kg/h.关键词
右美托咪定/卡前列素氨丁三醇/剖宫产Key words
dexmedetomidine/Carboprost Tromethamine/cesarean delivery引用本文复制引用
汪灵芝,廖敏,赖永东,何荣芝..不同剂量右美托咪定应用于剖宫产术中预防卡前列素氨丁三醇不良反应的对比研究[J].现代医院,2015,(7):18-20,3.基金项目
国家自然基金项目（编号81401017），广州市卫生局项目 （）
