现代医院Issue(7)：35-36,2.DOI:10.3969/j.issn.1671-332X.2015.07.013
交泰丸对 PCPA 大鼠失眠模型镇静催眠的效果研究
SEDATION AND HYPNOSIS EFFECT OF JIAOTAI PILLS ON RAT INSOMNIA IN PCPA RAT MODEL
廖小英 1周慧 2全世建3
作者信息
- 1. 广州市番禺区沙湾人民医院 广东广州 511483
- 2. 广州市番禺区市桥人民医院 广东广州 511490
- 3. 广东省中医药大学 广东广州 510405
- 折叠
摘要
Abstract
Objective To discuss the sedative and hypnotic effect of Jiaotai Pills on insomnia in PCPA rat model .Methods The PCPA ( PCPA acid) rats insomnia model was established, and the rats were divided into the model group, high, middle and low dosage of Jiaotai Pills group, and diazepam positive control group.The high performance liquid detective method was adopted to observe the effect of Jiaotai Pills on rat insomnia and hypothalamus neurotransmitters 5-HT and GABA.Results Compared with the model group, there existed significant difference in the insomnia state of rats and the central neurotransmitters 5 -HT in the high and middle dosages of Jiaotai Pill group and diazepam group.However, in the comparison of the high and middle dosages of Jiaotai Pill group and the model group, there was no significant difference in GABA in the central nervous system .Conclusion Jiaotai Pills has sedative and hypnotic efficacy.Its mechanism may be related to the effects of central neurotransmitter 5 -HT.Its relationship with GABA in the central nervous system is not obvious.The research has significant influence on the further development of Jiaotai Pills.关键词
交泰丸/高效液相检测方法/药效学研究Key words
Jiaotai Pill/high-performance liquid chromatography method for detection/pharmacodynamic study引用本文复制引用
廖小英,周慧,全世建..交泰丸对 PCPA 大鼠失眠模型镇静催眠的效果研究[J].现代医院,2015,(7):35-36,2.
