现代医药卫生Issue(9)：1300-1301,1304,3.DOI:10.3969/j.issn.1009-5519.2014.09.008
女性宫颈癌前病变快速HPV基因谱检查的价值研究
Value research of rapid HPV detection in female precancerous lesions of uterine cervix
夏凌志 1彭杰雄 1连丽琴 1徐萌2
作者信息
- 1. 深圳武警医院检验科，广东深圳518029
- 2. 深圳武警医院妇产科，广东深圳518029
- 折叠
摘要
Abstract
Objective To evaluate the clinical application values of human papilloma virus (HPV) testing in screening of women precancerous lesions of uterine cervix. Methods Cervical exfoliated cells from 282 hospitalized patients with cervical screening were collected,and the thinprep cytologic test(TCT) and HPV gene type test were conducted simultaneously. The TCT diagnosis included negative for intraepithelial lesion or malignancy (NILM),atypical squamous cells of undetermined significance (ASCUS),low-grade squamous intraepithelial lesion(LSIL),high-grade squamous intraepithelial lesion(HSIL) and squamous-cell carcinoma(SCC). The histopathologic examination was conducted to the patients with anomalous results,and the result of histopatho logic examination was regarded as golden standard of diagnosis. Results In HPV DNA positive group(n=126),the TCT showed 53 cases were of NILM,22 of ASCUS,32 of LSIL,18 of HSIL and 7 of SCC with the positive rate of histopathologic examination of 42.86%(54/126);while in HPVDNA negative group(n=156),the TCT showed 133 cases were of NILM,16 of ASCUS and 7 of LSIL with the positive rate of histopathologic examination of 11.54%(18/156). The comparison on positive rate of histopathologic examination between the two groups had statistically significant difference (χ2=35.96,P<0.01). High risk type HPV detection rate increased with the increased degree of cervical lesions. Conclusion HPV detection to female early cervical cancer and precan-cerous lesions of uterine cervix has important practical significance.关键词
癌前状态/宫颈上皮内瘤样病变/乳头状瘤病毒科/基因型/液基薄层细胞检测Key words
Precancerous conditions/Cervical intraepithelial neoplasia/Papillomaviridae/Genotype/Thinprep cytologic test引用本文复制引用
夏凌志,彭杰雄,连丽琴,徐萌..女性宫颈癌前病变快速HPV基因谱检查的价值研究[J].现代医药卫生,2014,(9):1300-1301,1304,3.
