现代医药卫生Issue(15)：2241-2242,2245,3.DOI:10.3969/j.issn.1009-5519.2014.15.001
广西壮族自治区壮族居民血小板抗原HPA-2基因分布频率研究
Study on genetic frequency of HPA-2 of Zhuang nationality in Guangxi Zhuang Autonomous Region
摘要
Abstract
Objective To determine the gene distribution frequency of human platelet antigen (HPA)-2 of Guangxi Zhuang Autonomous Region,so as to guide treatment decisions concerning platelet(PLT) transfusion. Methods The polymerase chain single nucleotide polymorphism was adopted to determine the genetic typing of HPA-2 among 2 659 health adults in Guangxi Zhuang Autonomous Region,and the direct sequencing was employed to resolve the genetic difference of HPA-2. Results Allele frequencies of HPA-2a/2a,HPA-2a/2b and HPA-2b/2b were 0.915 7,0.082 4 and 0.001 9,respectively. The detected gene poly-morphism site was completely identical to the information in database ,and no new single nucleotide polymorphism (SNP) site was discov ered. The degree of heterozygosis of HPA-2a/2b of Zhuang nationality was similar to the research results of most Asian counties,but compared with the African,the difference was significant. Conclusion This study contributes to determine the polymorphism distribution of HPA-2 in Guangxi and its potential clinical significance ,and it is beneficial to understand and treat immune-mediated PLA disease of Zhuang nationality.关键词
抗原,人血小板/广西壮族自治区/基因频率Key words
Antigens,human platelet/Guangxi/Gene frequency引用本文复制引用
廖燕,申卫东,李丽兰,周先果,何保仁,刘学军,刘金莲,黄惠妮..广西壮族自治区壮族居民血小板抗原HPA-2基因分布频率研究[J].现代医药卫生,2014,(15):2241-2242,2245,3.基金项目
广西壮族自治区卫生厅自筹课题（Z2010197）；广西壮族自治区青年科学基金项目（2012GXNSFBA053127）；广西壮族自治区自然科学基因青年基金项目（2013GXNSFBA019206）；南宁市科学研究与技术开发计划项目（201003048C-2）。 （）
