现代医药卫生Issue(15)：2268-2269,2272,3.DOI:10.3969/j.issn.1009-5519.2014.15.014
不同年龄段女性乳腺癌临床病理特点回顾性分析
Retrospective analysis of clinicopathological characteristics of female breast cancer in different ages
摘要
Abstract
Objective To retrospectively analyze the clinicopathological characteristics of female breast cancer in differ-ent ages and explore the clinical characters ,in order to provide experience for the clinical diagnosis and treatment of female breast cancer in difference ages. Methods The clinicopathologic data and related immunohistochemical indicators of 123 female pa-tients female breast cancer in difference ages ,who were diagnosed from January 2001 to December 2005 in the First Affiliated Hospital of Guangzhou Medical University,were collected and analyzed. Results According to the age distribution,the youth group(with the age≤35 years) accounted for 7.3%of all the breast cancer patients;the middle-age group(with the age of 36-60 years) accounted for 67.5%;the elderly group(with the age>60 years) accounted for 25.2%. The metastases rate of lymph nodes in breast cancer,the tumor size and histological grade(gradeⅡ/Ⅲ) in the youth group were obviously higher than those in the middle-age group and elderly group with statistically significant difference (P<0.05),and the difference had no statistical significant be-tween the middle-age group and the elderly group(P>0.05). According to the pathological types,there were 101 cases of non-spe-cial invasive breast cancer from all the breast cancer patients and 22 cases of special invasive breast cancer;cases of breast cancer were non-special invasive cancer in the youth group ,and non-special invasive breast cancer accounted for 81.9%in the middle-age group and 77.4%in the elderly group ,while the proportion of non-special invasive breast cancer in the youth group was obvi-ously higher than the middle-age group and elderly group,but the comparison among the three groups had no statistically signifi-cant difference(P>0.05). The positive expression rates of vascular endothelial growth factor (VEGF)-C/VEGF-D in youth group were 100.0%and 88.9%respectively,which were higher than those in the middle-age group(77.1%and 72.3%) and elderly group (70.9%and 67.7%),and the differences among the three groups had statistically significant difference (P>0.05). Conclusion 36-60 years old is the peak age of female breast cancer ,and the clinical pathological characteristics including metastases rate of lymph nodes in breast cancer,tumor size and histological grade and the positive expression rate of VEGF-C/VEGF-D in the youth group are higher than those in the middle-age group and elderly group with greater likelihood of malignant ,so early diagnosis and treatment should be paid attention clinically.关键词
乳腺肿瘤/发病年龄/免疫组织化学/病理学,临床Key words
Breast neoplasms/Age of onset/Immunohistochemistry/Pathology,clinical引用本文复制引用
黄榕权,李玉兰,庄静华,李仕芬,胡亚博,胡媛媛,谢燕清..不同年龄段女性乳腺癌临床病理特点回顾性分析[J].现代医药卫生,2014,(15):2268-2269,2272,3.基金项目
广州市市属高校科研项目（10A164）。 （）
