现代医药卫生Issue(17)：2563-2565,3.DOI:10.3969/j.issn.1009-5519.2014.17.002
初诊老年2型糖尿病患者血糖波动对氧化应激的影响
Effect of glucose variability on oxidative stress in newly-diagnosed elderly patients with T2DM
摘要
Abstract
Objective To investigate the effect of glucose variability on oxidative stress in newly-diagnosed elderly pa-tients with type 2 diabetes mellitus(T2DM),and compare the influence of repaglinide and gliclazide on glucose variability and ox-idative stress. Methods A total of 60 elderly patients with newly-diagnosed T2DM from January to December of 2013 were divid-ed into repaglinide group and gliclazide group,30 cases in each group,which received repaglinide and gliclazide respectively for 8-week treatment. The glucose variability was evaluated by mean amplitude of glycemic excursions (MAGE) and mean of daily differences(MODD) of continuous glucose monitoring system(CGMS),meanwhile to detect the Glutathione Peroxidase(GSH-Px), Superoxide Dismutase(SOD) and Maleic Dialdehyde(MDA) to reflect the level of oxidative stress. Results The levels of GSH-Px and SOD in elderly patients with T2DM were negatively related with MAGE and MODD(P<0.05),while the MDA level was positively related with MAGE and MODD(P<0.01). The levels of MAGE,MODD and MDA in both groups decreased after treat-ment,and the levels of serum GSH-Px and SOD increased,the difference of above indicators in both groups before and after treat-ment had statistical significance(P<0.01),but the comparison between the two groups on the above indicators showed no statisti-cally significant difference(P>0.05). Conclusion The serum oxidative stress levels are significantly correlated with glucose variability in newly-diagnosed elderly patients with T2DM. Both repaglinide and gliclazide can reduce the amplitude of glucose variability and oxidative stress levels in newly-diagnosed elderly patients with T2DM with similar effect.关键词
糖尿病,2型/糖尿病血管病变/血糖/氧化性应激/格列齐特/老年人/瑞格列奈Key words
Diabetes mellitus,type 2/Diabetic angiopathies/Blood glucose/Oxidative stress/Gliclazide/Aged/Repaglinide引用本文复制引用
罗娟,秦爱平,李浪波,陈凯..初诊老年2型糖尿病患者血糖波动对氧化应激的影响[J].现代医药卫生,2014,(17):2563-2565,3.基金项目
湖南省2012年科技基本项目投资计划（[2012]1493号）。 （）
