摘要
Abstract
Objective To analyze the clinic significance of serum cystatin C testing in diagnosis of renal injury associat-ed with pregnancy-induced hypertension syndrome. Methods Sixty patients,who were diagnosed with pregnancy-induced hy-pertension syndrome in inpatient service and outpatient department in the hospital from January 2012 to December 2013 ,were se-lected as observation group,which was divided into mild group(n=21),moderate group(n=20)and severe group(n=19);simulta-neously another 60 pregnant women undergoing physical examination in the hospital were chose as control group. The concentra-tions of serum cystatin C were detected in all respondents,meanwhile the conventional indexes related to renal function were also inspected;receiver operating characteristic(ROC) curve of the respondents was drawn and analyzed comprehensively. Results Compared with the control group,the levels of serum cystatin C, blood urea nitrogen(BUN) and creatinine(Cr) in the observation group increased significantly,and the difference had statistical significance(P<0.05). The positive detection rate of serum cystatin C of the observation group was more than 90.00%,and the mild group was 90.48%,which pairwise compared with the detection of BUN and Cr(61.90%,66.67%) respectively, the differences both had statistical significance(P<0.05);the pairwise comparisons of serum cystatin C on detection rate with BUN and Cr respectively in moderate group and severe group had no statistically signif-icant difference(P>0.05). The ROC curve analysis demonstrated the diagnostic efficiency of the three indexes for patients with pregnancy-induced hypertension syndrome in follows from high to low were serum cystatin C,Cr and BUN. Conclusion Cystatin C has higher sensitivity and clinical value for early renal damage of the patients with pregnancy-induced hypertension syndrome, which is worthy of clinical promotion.关键词
高血压,妊娠性/肌酸酐/血液/肾/损伤/妊娠高血压综合征/胱抑素C/尿素/肌酐Key words
Hypertension,Pregnancy-Induced/Creatinine/Blood/Kidney/injuries/Pregnancy-induced hyperten-sion syndrome/Cystatin C/Urea/Creatinine
