摘要
Abstract
Objective To investigate the correlated clinical parameters and the risk factors about diabetic peripheral neuropathy(DPN) of patients with type 2 diabetes mellitus(T2DM),and to analyze the possible mechanism. Methods A total of 205 hospitalized patients with T2DM were examined by electrophysiology and divided into DNP group(n=122) and non DPN group (NDPN group,n=83). The incidence of DPN were observed,the sex,age,course of disease,blood pressure,body mass index were recorded,and their correlated clinical parameters like glycosylated hemoglobin(HbAlc),uric microalbuminuria creatinine ratio (urinary A/C),serum creatinine,uric acid,triglyceride(TG),total serum cholesterol(TC) were detected. The resucts were analyzed by multivariate Logistic regression statistically. Results The incidence rate of DPN was 59.5%(122/205). Compared with the NDPN group,the DPN group had older age(t=-3.497,P=0.001),higher systolic blood pressure(t=-3.057,P=0.003),higher serum creatinine(t=-2.600,P=0.010) and uric A/C(t=-2.920,P=0.004),and the differences were all statistically significant(P<0.05). Multivariate Logistic regression analysis showed that the incidence of DPN was positively correlated with the age (OR=1.039, P=0.024) and urinary A/C(OR=1.005,P=0.010) in the DPN group. Conclusion The incidence of DPN in T2DM patients is high,and age and urinary A/C are the risk factors.关键词
糖尿病神经病变/周围神经系统疾病/糖尿病,2型/危险因素Key words
Diabetic neuropathies/Peripheral nervous system diseases/Diabetes mellitus,type 2/Risk factors
