现代医药卫生Issue(22)：3372-3373,3376,3.DOI:10.3969/j.issn.1009-5519.2014.22.006
七叶皂苷钠对脊髓半横断损伤大鼠后肢运动功能的影响
Influence of sodium aescinate on hindlimb movement in rats with hemisection of spinal cord injury
摘要
Abstract
Objective To observe the effect of sodium aescinate on hindlimb movement in rats with hemisection of spinal cord injury(hSCI ). Methods Thrity SD adult rats were selected and randomly divided into 3 groups:normal group(group A), normal saline group(group B) and sodium aescinate group(group C). The steady hSCI model of left lumbar(L2-3) was established in the group B and C,which was injected with normal saline and sodium aescinate respectively. The the Basson-Beattle-Bresnahan (BBB) rating scale and inclined plone(IP) test were adopted in all groups before operation and on 1st,3rd,5th d and 1st,2nd,3rd,4th week after operation. Results The rats of group B and C lost the left hindlimb movement function completely in a short period (1 d after operation),and the difference between the two groups on BBB scores 3 weeks after operation had statistical significance (P<0.05). 1 d after operation,the IP test results in group B and C decreased from from 85.0° to 12.5° around, then increased gradually with the time passage,4 weeks later,the difference on IP test results between group B and C had statistical significance(P<0.05). Conclusion The sodium aescinate can promote functional recovery of rats with hSCI.关键词
七叶素/脊髓损伤/大鼠/运动/后肢/生活质量Key words
Escin/Spinal cord injuries/Rats/Movement/Hindlimb/Quality of life引用本文复制引用
郑茂平,陈华东,李绍波..七叶皂苷钠对脊髓半横断损伤大鼠后肢运动功能的影响[J].现代医药卫生,2014,(22):3372-3373,3376,3.基金项目
云南省省级大学生科研项目（201210679002）。 （）
