现代医药卫生Issue(4)：497-499,3.DOI:10.3969/j.issn.1009-5519.2015.04.006
儿童热性惊厥血清神经元特异性烯醇化酶变化及其临床意义研究
Clinic significance of serum neuron specific enolase change of children with febrile seizure
摘要
Abstract
Objective To investigate the change and its significance of serum neuron specific enolase (NSE)in children with febrile seizure(FS). Methods According to the frequency and duration of FS,the research object was divided into four groups,i.e. group FS(simple FS,1 seizure lasting less than 15 min),group FS1(complex FS,2 seizure lasting less than 15 min), group FS2 (complex FS,1 seizure lasting more than 15 min) and the control group,50 cases in each group. It was adopted radio-im-muni-assay to detect the serum NSE concentration. Results The difference had no statistical significance in the concentration of serum NSE on the 1st and 7th days of FS between simple group FS and the control group[(15.16±1.68),(14.96±1.65)ng/mL respectively]vs.[(15.00±1.88)ng/mL,(14.82±1.46)ng/mL respectively](P>0.05),the concentrations of serum NSE in the group FS1,group FS2 on the 1st day was higher than those of the control group[(19.90±3.63)ng/mL vs. (27.44±9.34)ng/mL respectively]. There was statistical significance in difference(P<0.05). The concentrations of serum NSE in the group FS1,group FS2, whose FS duration was over 15 min was higher than those whose FS was repeated and short(>twice,<15 min)[(27.44±9.34 )ng/mL vs.(19.90± 3.63)ng/mL], whose difference had statistical significance(P<0.05). The concentrations of serum NSE[(16.61±3.32)ng/mL] of the FS patients lasted over 15 min on the 7th day was higher than that of the control group ,whose difference had statistical signifi-cance(P<0.05). Conclusion The serum NSE concentration after simple FS is normal. The neurons damage should be considered. The complex FS may lead to obvious neurons damage. The degree of long-time attack is heavier to neuron damage than that of re-peated short-time occurrence.关键词
磷酸丙酮酸水合酶/惊厥,发热性/儿童Key words
Phosphopyruvate hydratase/Seizures,febrile/Child引用本文复制引用
陈昭仪,范联,招顺万,林业辉,周杏,陈进喜,陈国华..儿童热性惊厥血清神经元特异性烯醇化酶变化及其临床意义研究[J].现代医药卫生,2015,(4):497-499,3.基金项目
广东省佛山市卫生局课题（2013170）。 （）
