摘要
Abstract
Objective To observe the clinic effect of dexmedetomidine combined with sufentanil for patient-controlled intravenous analgesia(PCIA) after thoracic tuberculosis surgery. Methods Sixty PCIA patients after thoracic tuberculosis surgery from June 2011 to September 2013 were randomly divided into 3 groups,20 cases in each group. Group A(the control group) was given 0.06μg/(kg·h)sufentanil deliquated to 100 mL with normal saline.Group B with 0.06μg/(kg·h) sufentanil combined with 0.05μg/(kg·h)dexmedetomidine. Group C with 0.06μg/(kg·h) sufentanil combined with 0.10μg/(kg·h) dexmedetomidine,all of which were added with 5 mg tropisetron deliquated to 100 mL with normal saline ,too. The mean arterial pressure (MAP),hear rate(HR),saturation of pulse oximetry(SpO2),VAS score,Ramsay sedation score,cumulative compression frequency within 24 hours,sufentanil consumption doses and side effects were also recorded at 2nd ,4th,6th,12th and 24th hours after the beginning of PCIA. Results There were no statistial significance in differences of MAP at various time in the group B ,C compared with group A(P>0.05). The HR in group B,C were significantly lower than those in group A at 2nd,4th,6th,12th and 24th hours af-ter PCIA while SpO2 in group B,C was higher than that of the control group at 4th,6th hours after PCIA,both of which had a sta-tistical significance in difference(P<0.05). It ranked from high to low of group A,B and C in VAS at 4th,6th,12th and 24th hours after PCIA,in turn,the Ramsay sedation score ranked. The difference was statistically significant (P<0.05). cumulative compression frequency within 24 hours,sufentanil consumption dosage and side effects such as nausea,vomiting and pruritus ordered group C, group B,group A,whose differece had a statistical significance(P<0.05). Conclusion Dexmedetomidine may strenghten intrave-nous sufentanil PCIA analgesic efficacy after thoracic tuberculosis surgery ,decrease sufentanil consumption doses and reduce the incidence of adverse effect.关键词
右美托咪啶/舒芬太尼/胸椎/结核/镇痛,病人控制Key words
Dexmedetomidine/Sufentanil/Thoracic vertebrae/Tuberculosis/Analgesia,patient-controlled
