现代医药卫生Issue(5)：645-647,650,4.DOI:10.3969/j.issn.1009-5519.2015.05.003
宫颈鳞癌组织中血管生成拟态及HIF-1α的表达
Vasculogenic mimicry in cervical squamous cell carcinoma tissues and the expression of HIF-1α
摘要
Abstract
Objective To study whether the vasculogenic mimicry in cervical squamous cell carcinoma tissues exists ,as well as its relationship and clinic pathological parameters between hypoxia-inducible factor-1α(HIF-1α) protein and invasion and metastasis of progress of cervical squamous cell carcinoma. Methods A total of 67 cervical squamous cell carcinoma resection specimens confirmed by pathology from January 2010 to December 2011 in the Affiliated Hospital of Luzhou Medical College were collected and detected whether it existed VM by CD34/PAS dual immunohistochemical staining. It adopted immunohistochemical staining to detect the expression of HIF-1αprotein in cervical squamous cell carcinoma tissues and analyze the association be-tween VM and HIF-1α,as well as its clinic pathological characters. In addition ,it selected 20 normal cervical tissues specimens underwent total hysterectomy for uterine fibroid as the control group. Results In the cervical squamous cell carcinoma tissues , the positive expression rate of VM and HIF-1αwas respectively 38.81%(26/67),64.18%(43/67),which was distinctively higher than that in the normal cervical tissues[0(0/20)]. The difference had statistical significance(P<0.05);The formation of VM was as-sociated with the FIGO staging, histology grading and lymphatic metastasis. The difference had statistical significance(P<0.05). The positive expression of HIF-1αprotein was associated with lymphatic metastasis and cancer size ,which was statistically signifi-cant in difference(P<0.05). There was a positive association between the expression of HIF-1αand VM(r=0.339,P <0.05). Conclusion VM exists in cervical squamous cell carcinoma tissues. Overexpression of HIF-1αmay induce the formation of VM. VM and jointly promote the invasion and metastasis of cervical squamous carcinoma.关键词
宫颈肿瘤/癌,鳞状细胞/缺氧诱导因子1,α亚基/免疫组织化学/血管生成拟态Key words
Uterine cervical neoplasms/Carcinoma,squamous cell/Hypoxia-inducible factor 1,alpha subunit/Immunohistochemistry/Vasculogenic mimicry引用本文复制引用
黄小环,向丽,龚莉,周铁军..宫颈鳞癌组织中血管生成拟态及HIF-1α的表达[J].现代医药卫生,2015,(5):645-647,650,4.基金项目
四川省教育厅科研基金资助项目（10ZB117）。 （）
