现代医药卫生Issue(10)：1453-1454,1457,3.DOI:10.3969/j.issn.1009-5519.2015.10.005
全身麻醉前长托宁联合阿托品与长托宁单用对老年患者术后谵妄的影响
Clinical therapeutic effect analysis of Penehyclidine Hydrochloride Injection uniting atropine and Penehyclidine Hydrochlo-ride Injection on elderly postoperative delirium
姜向春 1杨丽莹1
作者信息
- 1. 中国人民解放军第三二一医院，吉林白城137000
- 折叠
摘要
Abstract
Objective To compare diffrent clinical therapeutic effect of Penehyclidine Hydrochloride Injection uniting a-tropine and Penehyclidine Hydrochloride Injection on postoperative delirium of the elderly. Methods Selected 128 elderly ab-dominal surgery patients under general anesthesia and randomly divided them into uniting group ,Penehyclidine Hydrochloride Injection 1,Penehyclidine Hydrochloride Injection 2,and control group with 32 cases in each one. Gave 0.01 mg/kg Penehyclidine Hydrochloride Injection to Penehyclidine Hydrochloride Injection 1 through intramuscular injection ,0.005 mg/kg Penehyclidine Hydrochloride Injection to Penehyclidine Hydrochloride Injection 2 through intramuscular injection ,normal saline to control group through intramuscular injection 30 min before surgery,and put them all under general anesthesia. Gave 0.005 mg/kg Penehyclidine Hydrochloride Injection and 0.005 mg/kg to uniting group through intramuscular injection and carried delirium evaluation on 1 d before surgery and on 2,7 d after surgery using Nu-DESC-SCV,determined cognitive function on 1 d before surgery and of 72 h af-ter surgery using MMSE. The comparative analysis was performed. Results The MMSE ratings of Penehyclidine Hydrochloride Injection 1 reduced prominently and the Nu-DESC-SCV ratings of which rose prominently comparing to control group , differences showing statistic significance(P<0.05). The MMSE and Nu-DESC-SCV ratings of uniting group and Penehyclidine Hydrochloride Injection 2 reduced inapparently,differences showing no statistic significance(P>0.05). The delirium occurrence rate in the uniting group was clearly more than that in Penehyclidine Hydrochloride Injection 1,difference showing statistic significance(P<0.05). Conclusion Penehyclidine Hydrochloride Injection uniting atropine increases postoperative delirium in the elderly and should be used with caution in clinic.关键词
阿托品/奎宁环类/老年人/谵妄/手术后期间/治疗结果Key words
Atropine/Quinuclidines/Aged/Delirium/Postoperative period/Treatment outcome引用本文复制引用
姜向春,杨丽莹..全身麻醉前长托宁联合阿托品与长托宁单用对老年患者术后谵妄的影响[J].现代医药卫生,2015,(10):1453-1454,1457,3.
