协和医学杂志Issue(3)：270-272,3.DOI:10.3969/j.issn.1674-9081.2014.03.005
糖化血红蛋白浓度的短期生物学变异
Short-term Biological Variation of Glycated Hemoglobin-A1 c
李薇 1黄春梅 1吴卫 1胡莹莹 1陈倩 1郭野 1张玉娟 1崔巍1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院检验科，北京100730
- 折叠
摘要
Abstract
Objective To study the short-term biological variation of glycated hemoglobin-A1c (HbA1c). Methods Blood samples from 30 healthy volunteers [17 men and 13 women;aged 23-34 years ( median, 24 years)] were drawn at 8∶00 am, 12∶00 pm, and 4∶00 pm each day for 3 days (days 1, 3 and 5), and HbA1c values were measured in duplicate by high performance liquid chromatography ( Variant ⅡYurbo Analyser , Bio-Rad).Results The within-subject coefficient of variations (CVI) of total, male, and female subjects in this study were 1.39%, 1.49%, and 1.32%, respectively .The between-subject coefficient of variations ( CVG ) of the three groups mentioned above were 2.65%, 2.33%, and 2.90%, respectively .The analytical coefficient of variations (CVA) of these three groups were all 0.6%.The index of individuality (II) of the three groups were 0.5, 0.6, and 0.5, respectively.The 95%probabilities of reference change value (RCV) of the three groups were 4.22%, 4.45%, and 4.02%, respectively .The 99% probabilities of RCV were 5.19%, 5.86%, and 5.29%, respectively.Furthermore, intra-and inter-day biological variations of HbA1c were fairly constant among the population examined ( P=0.28, 0.31) , and no significant difference was observed between the male and fe-male participants (P=0.18).Conclusions The short-term CVI and CVG of HbA1c in healthy individuals are minimal.The laboratory findings are quite constant and homogeneous for HbA 1c in short term and between genders .关键词
糖化血红蛋白/生物学变异Key words
glycated hemoglobin-A1c/biological variation分类
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李薇,黄春梅,吴卫,胡莹莹,陈倩,郭野,张玉娟,崔巍..糖化血红蛋白浓度的短期生物学变异[J].协和医学杂志,2014,(3):270-272,3.
