摘要
Abstract
Objective To analyze the differences in clinicopathologic features and expressions of some im -munohistochemical indicators between triple negative breast cancer and non -triple negative breast cancer , and to investigate the relationship between clinicopathological features and immunohistochemical indicators .Methods A total of 863 patients (135 triple negative breast cancer and 728 non-triple negative breast cancer ) with his-topathologically confirmed breast cancer were collected in Peking Union Medical College Hospital from January 2010 to December 2013 .We retrospectively analyzed the difference in the onset age , histological subtype , tumor size, tumor differentiation, tumor stages, lymph node metastasis, nipple involvement and operation method be-tween triple negative breast cancer and non-triple negative breast cancer , then explored the difference between them in the expressions of estrogen receptor β(ERβ), epidermal growth factor receptor (EGFR), P53, and Ki67 by immunohistochemical staining .Prognostic factors of triple negative breast cancer were further discussed by univariate survival analysis .Results The proportion of invasive ductal carcinoma in triple negative breast cancer was higher than that in non-triple negative breast cancer ( 86.7% vs.65.2%, P<0.001 ); the age of onset was younger in triple negative breast cancer [(46.0 ±10.6) years vs.(51.0 ±3.3) years, P<0.05];significant differences were also found in lymph node metastasis , tumor size , differentiation grade , surgical proce-dure, and tumor stages between the two groups (P<0.05);no statistically significant inter-group difference in nipple involvement ( P >0.05 ) .Immunohistochemical results showed that compared with non-triple negative breast cancer , ERβexpression rate decreased significantly ( 63.7% vs.75.6%, P <0.05 ) while EGFR expression rate increased significantly in triple negative breast cancer ( 62.2% vs.33.3%, P <0.05 ); the expression of P53 and Ki67 demonstrated no significant difference (P>0.05).The overall survival (OS) and relapse-free survival ( RFS) were both lower in triple negative breast cancer ( P<0.05 ) .Univariate survival analysis showed that both ERβnegative expression and EGFR positive expression were related to the poor progno -sis of triple negative breast cancer ( P<0.05 ) .Conclusions Compared with non-triple negative breast cancer , triple negative breast cancer shows completely different clinicopathological features :younger age of onset , larger tumor size , lower degree of differentiation , higher incidence of lymph node metastasis , lower ERβexpression , higher EGFR expression , and lower OS and RFS .ERβand EGFR may be important prognostic indicators in tri-ple negative breast cancer .关键词
三阴乳腺癌/雌激素受体β/表皮生长因子受体/临床病理特征/预后Key words
triple negative breast cancer/estrogen receptor β/epidermal growth factor receptor/clinicopathological fea-tures/prognosis分类
医药卫生
