心理科学进展Issue(7)：1187-1195,9.DOI:10.3724/SP.J.1042.2015.01187
基于“心理痛苦”理论的眶额皮质介导抑郁症自杀机制
Neural Circuits of Orbitofrontal Cortex Involved in Suicidal Attempts Among Major Depression Patients
摘要
Abstract
For a suicidal person, suicide seems to be the only means of escaping the torment of psychological pain. Pain avoidance, representing the wish to escape psychological pain, may be a primary predictor of subsequent suicide. Given that the Orbitofrontal cortex dysfunction may trigger overreaction to a social signal of disapproval (painful feelings) and induced high level motivation for escaping from punishment (pain avoidance), event-related functional MRI was used to measure orbitofrontal cortex and its neural circuit activity in response to stimuli representing negative/positive emotional incentives among patients with a history of suicidal attempts (vs.no suicidal history) in furture work. Our work will extend interactive modes of motivation and cognitive control circuits underying higher levels of psychological pain and ultimately may provide a empiral evidence for the neural correlates of pain avoidance which trigger suicidal behavior.关键词
心理痛苦/痛苦逃避/抑郁/自杀/眶额皮质Key words
suicidal attempt/depression/psychological pain/pain avoidance/orbitofrontal cortex分类
医药卫生引用本文复制引用
李欢欢,谢蔚臻,李永娜..基于“心理痛苦”理论的眶额皮质介导抑郁症自杀机制[J].心理科学进展,2015,(7):1187-1195,9.基金项目
国家自然科学基金(81401120)、中国科学院心理研究所心理健康重点实验室开放课题和中国人民大学团队预研项目基金(14XNLQ05)资助。 （81401120）
