西南国防医药Issue(5)：476-478,3.DOI:10.3969/j.issn.1004-0188.2014.05.005
CYP2 C9-1061 A／C基因多态性对特发性房颤患者华法林用量的影响
Effects of CYP2C9-1061A/C gene polymorphism on dosage of warfarin for patients with idiopathic paroxysmal atrial fibrillation
摘要
Abstract
Objective To explore the distribution of CYP2C9-1061A/C gene polymorphism in patients with idiopathic paroxysmal atrial fibrillation in Guangdong area and its effects on the dosage of warfarin .Methods 150 patients with idiopathic atrial paroxysmal fibrillation from Guangdong area were considered as patient group ,and 120 healthy people from the same area were regarded as control group.The difference of the distribution of CYP2C9-1061A/C gene polymorphism detected by PCR-RFLP between the 2 groups was compared and the difference of dosage of warfarin for the patients with different genotype was analyzed each other .Results The CYP2C9 gene fragment was cut into 134 bp and 18 bp by KpnⅠenzyme after the A base was mutated by C base .There were 105 patients (70.0%) with AA type,40 ones (26.7%) with AC type and 5 ones (3.3%) with CC type.Compared with the normal people,the ratio of AC type in patients with idiopathic paroxysmal atrial fibrillation was higher (χ2 =13.3259,P=0.0003),AA ratio was lower(χ2 =14.5200,P=0.0000),but CC ratio was not different obviously (χ2 =0.2218,P=0.6377).The dosage of warfarin for patients with AC and CC type [(3.62 ±0.58)mg,(3.12 ±0.16)mg] was lower than that with AA type[(4.28 ±0.63)mg](P<0.01),and the dosage of warfarin for patients with CC type was lower than that with AC type (P<0.05).Conclusions There are more CYP2C9-1061A/C gene polymorphism in patients with idiopathic paroxysmal atrial fibrillation in Guangdong area .The mutation of CYP2C9-1061A/C decreases the dosage of warfarin .Therefore, CYP2C9 gene polymorphism can be used as reference to the personalized dosage regimen of warfarin in patients with idiopathic atrial paroxysmal fibrillation .关键词
特发性房颤/CYP2C9/基因多态性/华法林Key words
idiopathic paroxysmal atrial fibrillation/CYP2CP/gene polymorphism/warfarin分类
医药卫生引用本文复制引用
李锐,邱健,马骏,黎建安,何建新,阮云军,肖华,张园,叶丽丽..CYP2 C9-1061 A／C基因多态性对特发性房颤患者华法林用量的影响[J].西南国防医药,2014,(5):476-478,3.基金项目
广东省医学科学技术研究基金 （）
