西南国防医药Issue(10)：1094-1097,4.DOI:10.3969/j.issn.1004-0188.2014.10.019
CSF 的影响因素及瑞舒伐他汀、尼可地尔的联合疗效研究
Study on influencing factors of CSF and combined treatment efficacy of rosuvastatin and nicorandil
陆卫华 1杨剑虹 1方庆 1李刚 1丁世芳1
作者信息
- 1. 430070 武汉，广州军区武汉总医院急诊科
- 折叠
摘要
Abstract
Objective To study the influencing factors of coronary slow flow( CSF)and combined treatment efficacy of rosuvastatin and nicorandil. Methods Total 60 CSF patients who received treatment in our hospital from Jun. of 2011 to Dec. of 2013 and other 60 patients whose coronary angiography and blood flow were normal in the same period were selected. Multi-factor logistic regression analysis was made in order to find the influencing factors inducing CSF. The CSF patients were randomly divided into nicorandil group and combined treatment group;the patients in nicorandil group took nicorandil tablet of 10 mg orally,3 times a day;while the patients in the combined treatment group took rosuvastatin tablet of 10 mg orally each day in addition to nicorandil tablet as nicorandil group. Before the treatment and 3 months after treatment,their liver function,concentration of high sensitive C reactive protein (hs-CRP),and brachial artery flow mediated(FMD)vascular dilation function were tested. Results The total cholesterol(TC,OR =3. 10),low-density lipoprotein cholesterol( LDL-C,OR = 4. 35),hs-CRP( OR = 3. 25),flow mediated dilation( FMD,OR = 0. 59), smoking(OR = 5. 93),diabetes mellitus(OR = 8. 25)were all influencing factors of CSF(P < 0. 05). After 3 months of treatment,FMD, hs-CRP,and the blood flow velocity of left anterior descending branch,left circumflex branch and right coronary artery of the two groups were significantly improved than those before the treatment(P < 0. 05);besides,the combined treatment group improved more greatly than nicorandil group(P < 0. 05). Conclusion Rosuvastatin and nicorandil are of synergistic effects;combined administration of them can better improve the endothelial function and coronary flow velocity,and the treatment efficacy for CSF is better than only use of nicorandil.关键词
冠状动脉慢血流/瑞舒伐他汀/尼可地尔/疗效Key words
coronary slow flow/rosuvastatin/nicorandil/curative effect分类
医药卫生引用本文复制引用
陆卫华,杨剑虹,方庆,李刚,丁世芳..CSF 的影响因素及瑞舒伐他汀、尼可地尔的联合疗效研究[J].西南国防医药,2014,(10):1094-1097,4.
