摘要
Abstract
Objective To analyze the high risk factors of malignant transformation of hydatidiform mole(HM)and effects of preventive chemotherapy and operation. Methods Total 248 patients with HM receiving treatment in our hospital from June of 2005 to June of 2013 were surveyed,respectively. The survey indexes included the patientsˊage,relationship between the uterine size and the pregnancy,serum human chorionic gonadotropin levels,ovarian lutein cyst size,whether or not HM occurred repeatedly,and high risk factors of malignant transformation of HM,etc. All patients received uterine aspiration therapy;those who had one of the high risk factors but had no follow-up conditions received preventive chemotherapy;those who were more than 40 years old,had no fertility requirements and had high risk factors of malignant transformation but no follow-up conditions received hysterectomy. Results The ratio of malignant transformation of HM of the patients having high risk factors( more than 40 years old;the uterus was larger than that in the corresponding month of menopause,the value of serum hCG was higher than 105 U/L,and the diameter of ovarian lutein cyst was equal to or greater than 6 cm;having a history of HM)was significantly higher than that of those who had no high risk factors(P<0. 05),but the degrees were different,and the ratio of those whose diameter of ovarian lutein cyst was equal to or greater than 6 cm was the highest. The ratio of malignant transformation of the patients who had received preventive chemotherapy or operation was 8. 3% and 3. 3%, respectively,significantly lower than those receiving no preventive chemotherapy or operation of 35. 9%(P<0. 05). Conclusion The high risk factors lead to a significantly increased ratio of malignant transformation of HM,but the degrees are different;preventive chemotherapy or operation can reduce the incidence of malignant transformation of HM of the patients with high risk factors.关键词
葡萄胎/高危因素/预防性化疗/全子宫切除术Key words
hydatidiform mole/high risk factors/preventive chemotherapy/hysterectomy分类
医药卫生
