西南国防医药Issue(11)：1234-1236,1237,4.DOI:10.3969/j.issn.1004-0188.2014.11.031
氧疗对移居3700 m高原缺氧损伤预防作用的现场研究
Field study of prevention of oxygen therapy from hypoxic injury in migrators at 3700 m high altitude above sea level
摘要
Abstract
Objective To explore the prevention of oxygen therapy from hypoxic injury in migrators at 3700 m high altitude. Methods Total 120 young males who had lived in 3700 m high altitude above sea level for more than one year were selected and divided randomly into group A(inhaling oxygen for 30 min per day,n=40),group B(inhaling oxygen for one hour per day,n=40), and group C( no oxygen inhalation,n=40 ). The oxygen flow rate was two liters per minute and the inhaling time was 30 consecutive days. Chronic mountain sickness( CMS )symptom scores,sleep quality score,hemoglobin( Hb )concentration,HR,blood pressure, respiratory rate,SaO2 and performance in 1000 m run were examined and evaluated before the oxygen inhalation,after 15 day and 30 day oxygen inhalation,and after oxygen inhalation had been stopped for 15 days,respectively. Results The sleep quality score of the subjects in group B after 15 day and 30 day oxygen inhalations was lower than that before the oxygen inhalation( P <0. 05 or P<0. 01). The CMS symptom score and sleep quality score of the subjects in group A after 15 day and 30 day oxygen inhalations were lower than that in group B(P<0. 05 or P<0. 01);SaO2 of the subjects in both group A and B increased after 30 day oxygen inhalation in comparison with that before the oxygen inhalation(P<0. 01). Besides,in comparison with group C,the CMS symptom score and Hb concentration of both group A and B decreased but SaO2 increased after 15 day and 30 day oxygen inhalations and after oxygen inhalation had been stopped for 15 days(P<0. 05 or P<0. 01). Conclusion Long-term low-concentration oxygen therapy can prevent chronic mountain sickness,improve sleep quality,stabilize or reduce the increase of Hb concentration. The effect of oxygen inhalation for one hour every day will be better than that for 30 minutes. After oxygen inhalation is stopped for 15 days,the physiological indexes will recover to the level before the oxygen inhalation.关键词
高原/氧疗/CMS/睡眠质量/SaO2Key words
plateau/oxygen therapy/CMS/sleep quality/SaO2分类
医药卫生引用本文复制引用
崔建华,崔宇,张俊才,高亮,张一新,王福领,高钰琪,张钢,黄缄..氧疗对移居3700 m高原缺氧损伤预防作用的现场研究[J].西南国防医药,2014,(11):1234-1236,1237,4.基金项目
军队重大专项（13KJZ01）；高原医学教育部重点实验室资助项目 （）
