西南国防医药Issue(3)：258-260,3.DOI:10.3969/j.issn.1004-0188.2015.03.010
阿托伐他汀对高血压患者炎症因子IL-8、IL-1β及IMT的干预作用
Intervention effect of atorvastatin on inflammatory factors IL-8, IL-1βand IMT in patients with hypertension
梁彦丽 1王先梅1
作者信息
- 1. 650032 昆明，昆明医科大学成都军区昆明总医院临床学院、成都军区昆明总医院心血管内科
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摘要
Abstract
Objective To explore the effect of atorvastatin calcium on interleukin-8 ( IL-8 ) , interleukin 1β( IL-1β) and carotid artery intima-media thickness ( IMT ) in patients with hypertension .Methods A retrospective analysis was made for 150 patients with primary hypertension to receive treatment in our hospital in 2012.The patients were divided randomly into the experimental group , clinical group , and control group .The experimental group was administered with atorvastatin calcium of 20 mg and Nifedipine Controlled Release Tablets of 30 mg; the clinical group was administered with perindopril of 8 mg, Nifedipine Controlled Release Tablets of 30 mg, and atorvastatin calcium of 20 mg; the control group was administered with perindopril of 8 mg and Nifedipine Controlled Release Tablets of 30 mg.The administering periods of three groups were all six months .ELISA method was used to determine the serum levels of IL-8 and IL-1βbefore and after the drug administration , and ultrasonography was used to measure the IMT thickness of cervical vascular system before and after the administration .Results The IL-8 and IL-1βconcentration and IMT in both experimental and clinical groups were lower than those in the control group , and the IL-8, IL-1βand IMT in the clinical group were lower than those in the experimental group (P <0.05).Conclusion Atorvastatin can reduce the expression levels of inflammatory cytokines IL-8, IL-1βand IMT in patients with hypertension , and perindopril combined with atorvastatin has a reinforced anti-inflammatory effect .关键词
高血压/阿托伐他汀/白细胞介素/IMTKey words
hypertension/atorvastatin/interleukin/IMT分类
医药卫生引用本文复制引用
梁彦丽,王先梅..阿托伐他汀对高血压患者炎症因子IL-8、IL-1β及IMT的干预作用[J].西南国防医药,2015,(3):258-260,3.
