西南国防医药Issue(6)：584-586,587,4.DOI:10.3969/j.issn.1004-0188.2015.06.002
预注右美托咪定对LC患者拔管期BIS指数和复苏的影响
摘要
Abstract
To study the effects of dexmedetomidine preinjection before total intravenous anesthesia induction on bispectral (BIS) index and recovery in patients receiving laparoscopic cholecystectomy (LC) during extubation period. Total 64 patients receiving LC were randomly divided into dexmedetomidine group (group D) and control group (group C) (n=32 per group). Before total intravenous anesthesia induction, small doses of dexmedetomidine were injected by micro pumps in group D (0.5 μg/kg), and normal saline was administered in group C within 10 min. All patients were treated with propofol-remifentanil target controlled infusion (TCI) for total intravenous anesthesia, and intraoperative routine life signs monitoring was provided. The BIS index was recorded before operation (T0), upon stop of TCI (T1), in 5 min after stop of TCI (T2), upon recovery of spontaneous breathing (T3), upon recovery of consciousness (T4), during extubation (T5) and in 5 min after extubation (T6). The time period from the stop of TCI to that when BIS index reached to 65, 75, 85, and 95 and the time points of respiration recovery, extubation, and consciousness recovery were recorded, respectively. The incidences of adverse reactions of patients within 20 min after the extubation were compared between two groups. (1)The BIS values in group D from T2 to T3 were lower than that in group C ( < 0.05), and those from T4 to T6 had no significant difference from those in group C ( >0.05). (2) The time periods for BIS values in group D to reach to 65 and 75 were longer than those in group C ( < 0.05), but those for BIS values in group D to reach to 85 and 95 as well as the time points of respiration recovery, extubation, and consciousness recovery showed no significant difference from those in group C ( >0.05). (3) During the extubation period, the incidences of cough, restlessness, nausea and vomiting, and cycle fluctuations in group D were significantly less than those in group C ( < 0.05). Preinjection of small doses of dexmedetomidine before intravenous anesthesia induction does not affect the postoperative awaking and recovery time of patients receiving LC, but it can reduce adverse reactions during extubation period.关键词
右美托咪定/脑电双频指数/复苏/拔管期Key words
dexmedetomidine/BIS index/recovery/extubation period分类
医药卫生引用本文复制引用
林露,冉茂荣,李军..预注右美托咪定对LC患者拔管期BIS指数和复苏的影响[J].西南国防医药,2015,(6):584-586,587,4.基金项目
成都军区医学科学技术研究计划重点项目 （）
