心脑血管病防治Issue(1)：18-20,3.DOI:10.3969/j.issn.1009816x.2015.01.07
2型糖尿病动脉粥样硬化患者 CD4＋CD28null T 细胞亚群的表达及意义
Significance and Expression of CD4+CD28nul T Cell Subset on Progression of Atherosclerosis in Patients with Type 2 Dia-betes
摘要
Abstract
Objective To investigate the effect of CD4+CD28nul T cell subset on occurrence and progress of atherosclerosis in patients with type 2 diabetes. Methods 92 patients with type 2 diabetes were divided into the carotid atherosclerosis group and control group according to the detecting results by color doppler ultrasound. The expressions of CD4+CD28nul T cell subset in peripheral blood of the carotid atherosclerosis and control groups were detected by a flow cytometry. The relationships between the expression of CD4+CD28nul T cell subset and age ,C react protein (CRP) ,blood glucose ,blood lipid ,body mass index (BMI) ,waist circumference , hip circumference ,diastolic blood pressure ,systolic blood pressure were also analyzed. Results The expression of CD4+CD28nul T cell subset of the carotid atherosclerosis group is significantly higher than that of the control group (4.40 ± 2.95% vs. 3.04 ± 2.20% , P<0.05). The expressions of CD4+CD28nul T cell subset were correlated with age ,CRP ,Hemoglobin A1C (HbA1c) (r-0.20~0.25 ,P<0.05). After controlling the factors of age and HbA1c ,the expression of CD4+CD28nul T cell subset was still relevant with CRP (r=0.24 ,P<0.05).Conclusions The type 2 diabetes patients with atherosclerosis have a higher expression of CD4+CD28nul T lymphocyte. CD4+CD28nul T cell subset may affect the occurrence and process of atherosclerosis via mediated in-flammatory response in the patients with type 2 diabetes.关键词
糖尿病/T细胞亚群/多普勒超声Key words
Diabetes/T cell subset/Doppler ultrasound分类
医药卫生引用本文复制引用
汤珂珂,高祖华,邱夏桑,颜勤明..2型糖尿病动脉粥样硬化患者 CD4＋CD28null T 细胞亚群的表达及意义[J].心脑血管病防治,2015,(1):18-20,3.基金项目
浙江省医药卫生科技计划项目（编号2011KYA160）；浙江省台州市科技计划项目 （）
