心脑血管病防治Issue(1)：24-26,3.DOI:10.3969/j.issn.1009816x.2015.01.09
金匮肾气丸对阿尔茨海默病大鼠模型海马神经元β淀粉样蛋白和神经元核抗原表达的作用
Effects of Jin Kui Shen Qi Wan on Expression of Beta amyloid and NeuN in Hippocampal Neurons of Alzheimer ’s Disease Model Rats
摘要
Abstract
Objective To evaluate the impact of jin kui shen qi wan on expression of Beta amyloid and NeuN in hippocampal neurons of Alzheimer’s disease model rats. Methods 24 clean healthy SD rats were randomly divided into three groups :control group ,the AD model group ,TCM group. Adopt unilateral hippocampal injection of Aβ25 35 to establish AD model SABC immunohistochemical method to detect the expression of Beta amyloid and NeuN in hippocampal neurons . Results ① AD model group compared with the control group rats hippocampus Beta amyloid positive cells increased ( P<0.01 ) NeuN positive cells decreased ( P<0.01 );②TCM group compared with the AD model group ,Beta amyloid positive cells in rat hippocampus ( P<0.01) reduction in NeuN posi-tive cells increased ( P<0.01 ). Conclusions Jin kui shen qi wan ,prevention and treatment of AD ,its role and inhibition of Beta amyloid positive cells expressed the party has to promote the expression of NeuN positive cells .关键词
阿尔茨海默病/海马/金匮肾气丸/β淀粉样蛋白/神经元核抗原Key words
Alzheimer’s disease/Hippocampus/Jin kui shen qi wan/Beta amyloid/NeuN分类
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方兰,张渊,吴英..金匮肾气丸对阿尔茨海默病大鼠模型海马神经元β淀粉样蛋白和神经元核抗原表达的作用[J].心脑血管病防治,2015,(1):24-26,3.
