心脑血管病防治Issue(2)：90-93,4.DOI:10.3969/j.issn.1009_816x.2015.02.02
环氧化酶在炎症因子引起冠状动脉无复流现象中的作用机制研究
Mechanism of Action of Cyclooxygenase in Inflammatory Factor Inducing No_reflow of Coronary Artery
摘要
Abstract
Objective To explore the effects and molecular mechanisms of cyclooxygenase (COX1 ,2) on inflammatory factor induc-ing no-reflow of coronary artery.Methods Forty_four patients were enrolled.The serum inflammatory factors levels (CRP and IL_6) of preoperative PCI were measured with the drug_eluting stents ,to investigate whether the inflammatory factor differs in no_reflow and normal reflow patients.Human coronary artery endothelial cells (HCAEC) model ,which were simulated by CPR ,were cultivated to analyze the expression of gene and protein ,and to discuss the mechanism of action of CRP in no_reflow situation.Results The CRP and IL_6 levels of patients in no_reflow group were significantly higher than those in normal reflow group ,there were statistically sig-nificant differences ( P<0.05).In the CRP simulated HCAEC model ,the expressions of COX in CRP_simulated group was higher than that of the control group ,and it decreased significantly after using the extracellular signal_regulated kinase (ERK1/2 ) and jun n_terminal kinase (JNK 1/2) inhibitor ,there were statistically significant differences ( P<0.01).Conclusions By activating the path-ways of COX inflammation ,CRP could cause no_reflow after AMI emergency PCI.关键词
环氧化酶/炎症因子/C_反应蛋白/冠状动脉/无复流Key words
Cyclooxygenase/Inflammatory factors C_reactive protein/Coronary Artery/No_reflow phenomenon分类
医药卫生引用本文复制引用
杨栋,焦其彬,柯强,李薇薇,张邢炜..环氧化酶在炎症因子引起冠状动脉无复流现象中的作用机制研究[J].心脑血管病防治,2015,(2):90-93,4.基金项目
浙江省科技厅科技计划（编号2008C30039）；杭州市科技局医学重点专科专病项目（编号20090833 Q08）；杭州市卫生局卫生科技计划项目 （）
