新医学Issue(8)：505-508,4.DOI:10.3969/g.issn.0253-9802.2014.08.004
维持性血液透析患者血清尿酸水平与死亡风险的关系分析
Relationship between elevated serum uric acid and mortality risk in hemodialysis patients
摘要
Abstract
Objective Toexploretheassociationbetweenelevatedserumuricacid(SUA)andmor-talityriskinhemodialysispatients.Methods Atotalof982patientswhounderwenthemodialysisinGeneral Hospital of Guangzhou Military Command of PLA from January 2008 to January 201 3 were recruited in this study and categorized into three groups according to SUA concentration by Tertile analysis. Death was deemed as the end-point event. Cox regression models were used to evaluate the relationship between uric acid tertiles and all-cause mortality. Kaplan-Meier survival analysis and Cox regression models were adopted to assess the cumulativeall-causemortalityamongthreegroups.Results Intotal,982hemodialysispatientshadamean follow-up of 25.3 months and a maximum duration up to 72.0 months. The mean concentration of serum SUA was 41 8 mmol/L (range:223~1 1 76 mmol/L). Regarding Tertile II of SUA as the reference standard (399~440 mmol/L),the patients with Tertile III of SUA (441 ~1 1 24 mmol/L)had a significantly higher mortality with an all-cause mortality ratio of 1.46 after adjustment (95% CI 1.23 ~1.77,P<0.001 ). However,the risk of all-cause and CVD mortality between Tertile I (238~398 mmol/L)and II groups did not significantly differ (P>0.05 ). Kaplan-Meier survival analysis and Cox regression models revealed that no association was found between SUA levels and all-cause mortality in all groups. After adjustment of confounding factors,the survivalrateintheTertileIIIgroupwasthelowest(P=0.003).Conclusion ElevatedlevelsofSUAcould increase the mortality risk of patients undergoing hemodialysis.关键词
血清尿酸/血液透析/流行病学/死亡风险Key words
Serumuricacid/Hemodialysis/Epidemiology/Mortalityrisk引用本文复制引用
李小庭,童俊容,张虹,谢晓萍,李小莲..维持性血液透析患者血清尿酸水平与死亡风险的关系分析[J].新医学,2014,(8):505-508,4.基金项目
国家自然科学基金资助项目 （）
