新医学Issue(10)：656-658,3.DOI:10.3969/g.issn.0253-9802.2014.10.006
三氯乙烯药疹样皮炎患者血清甲状腺素水平的观察
Determination on the level of serum thyroid hormone in patients with trichloroethylene-induced medica-mentosa-like dermatitis
摘要
Abstract
Objective To observe the changes in the serum level of thyroid hormone in patients with trichloroethylene (TCE)-induced medicamentosa-like dermatitis.Methods Sixty five patients diagnosed with TCE-induced medicamentosa-like dermatitis were enrolled in this study between January 2009 and Decem-ber 201 3.Sixty five healthy subjects were used as normal controls.Serum levels of thyroid-stimulating hormone (TSH),free triiodothyronine (FT3 )and free thyroxine (FT4 )were measured using chemiluminescence meth-od.Total dose of steroid hormones administered for all patients with TCE-induced medicamentosa-like dermati-tis was statistically calculated.Results The serum levels of thyroid hormones in TCE-induced medicamentosa-like dermatitis patients were significantly lower than those in healthy controls:FT3 (2.86 ±1 .56 vs.4.70 ± 0.92 pmol/L),FT4 (8.86 ±5.1 5 vs.1 6.07 ±3.02 pmol/L)and TSH (1 .23 ±1 .28 vs.2.71 ±1 .35 mIu/L)(all P <0.01 ).The serum levels of thyroid hormones in the high-dose group were significantly lower com-pared with those in the low-dose group:FT3 (1 .39 ±0.81 vs.1 .39 ±0.81 pmol/L),FT4 (4.1 2 ±2.83 vs.1 1 .81 ±3.92 pmol/L)and TSH (0.41 ±0.1 5 vs.1 .75 ±1 .40 mIu/l)(all P <0.01 ).Conclusions The serum levels of thyroid hormones in TCE-induced medicamentosa-like dermatitis patients are significantly lower than those in healthy counterparts.Detection of thyroid hormone levels is beneficial to the evaluation of the se-verity and prognosis for this disease.关键词
三氯乙烯药疹样皮炎/游离三碘甲状腺原氨酸/游离四碘甲状腺原氨酸/促甲状腺素Key words
Trichloroethylene-induced medicamentosa-like dermatitis/Free triiodothyronine/Free thyroxine/Thyrotropin引用本文复制引用
王金林,李智民,张健杰,邓立华,邱少宏,唐玉宏,司徒洁,钦卓辉,韦始亮,李辉..三氯乙烯药疹样皮炎患者血清甲状腺素水平的观察[J].新医学,2014,(10):656-658,3.基金项目
国家职业病临床重点专科建设项目（WY2011873）；深圳市科技局计划资助项目 （）
