新医学Issue(10)：659-662,4.DOI:10.3969/g.issn.0253-9802.2014.10.007
17例淋巴瘤相关噬血细胞综合征的临床特点及疗效分析
Clinical characteristics and therapeutic effect of 17 cases of lymphoma-associated hemophagocytic syn-drome
李旭东 1王东宁 1何易 1胡元 1王文文 1黄仁魏1
作者信息
- 1. 510630 广州，中山大学附属第三医院血液科
- 折叠
摘要
Abstract
Objective To summarize the clinical characteristics and therapeutic effect of 1 7 cases of lymphoma-associated hemophagocytic syndrome (LAHS).Methods The clinical data were analyzed to sum-marize the clinical features and therapeutic effect of 1 7 patients with LAHS.Results High-grade fever,high serum level of ferritin and hemophagocytosis were observed in 1 7 cases,cytopenia and hypertriglyceridemia in 1 6,splenomegaly in 1 5 and hypofibrinogenemia in 1 4.Two patients who received chemotherapy and then allo-geneic peripheral blood stem cell transplantation (allo-PBSCT)survived for 45 and 37 months.One case un-dergoing chemotherapy and then autologous peripheral blood stem cell transplantation (auto-PBSCT)died of in-fection at postoperative 1 5 months.Among 1 3 patients who received chemotherapy alone,only 1 case survived for 1 5 months after 8 cycles of chemotherapy and the other 1 2 died with a survival time ranging from 3 to 1 3 months.One case died one week after admission without any treatment.Conclusions LAHS is characterized as acute onset,severe condition,high-grade fever,hypertriglyceridemia,cytopenia,hemophagocytosis,high serum level of ferritin and hypertriglyceridemia.Chemotherapy yields relatively poor therapeutic effect,whereas allo-PBSCT may serve as an efficacious treatment of LAHS.关键词
噬血细胞综合征/淋巴瘤/临床特点/疗效Key words
Hemophagocytic syndrome/Lymphoma/Clinical characteristics/Therapeutic effect引用本文复制引用
李旭东,王东宁,何易,胡元,王文文,黄仁魏..17例淋巴瘤相关噬血细胞综合征的临床特点及疗效分析[J].新医学,2014,(10):659-662,4.
