新医学Issue(10)：675-679,5.DOI:10.3969/g.issn.0253-9802.2014.10.011
血清内脂素水平与多囊卵巢综合征的相关性研究
Correlation between serum visfatin and polycystic ovary syndrome
摘要
Abstract
Objective To explore the relationship among serum visfatin and insulin resistance (IR) and obesity in women with polycystic ovary syndrome (PCOS).Methods Twenty-three patients with PCOS were assigned into the PCOS group and 1 5 normal subjects allocated into the control group.Based upon body mass index (BMI),the PCOS group was divided into the obesity (BMI≥25,n =8)and non-obesity groups (BMI <25,n =1 5),and the control group into the obesity (n =7)and non-obesity groups (n =8).During early follicular period,sex hormone,fasting plasma glucose (FPG)and fasting insulin (FINS)were detected.Body mass index (BMI),waist to hip ratio (WHR)and homeostasis model assessment-insulin resistance (HOMA-IR)were calculated.The concentration of serum visfatin was assayed by ELISA.Results Serum visfatin in PCOS patients was significantly higher compared with that in normal controls (P <0.05).The serum level of visfatin in obese PCOS women was significantly higher than that in obese normal controls (P <0.05), whereas no statistical significance was observed in non-obese subjects between PCOS and control groups (P >0.05).Correlation analysis revealed that serum levels of visfatin were positively correlated with BMI,T,FPG, FINS and HOMA-IR (all P <0.05).Conclusions Abnormal metabolism of serum visfatin could be observed in women with PCOS.Increased serum visfatin may be correlated with obesity and IR.Serum visfatin may serve as one of the predictors for the severity of IR in PCOS women.关键词
多囊卵巢综合征/内脂素/胰岛素抵抗/肥胖Key words
Polycystic ovary syndrome/Visfatin/Insulin resistance/Obesity引用本文复制引用
苏淑军,张添松,古健..血清内脂素水平与多囊卵巢综合征的相关性研究[J].新医学,2014,(10):675-679,5.基金项目
广东省社会发展领域科技计划项目 （）
