新医学Issue(11)：758-762,5.DOI:10.3969/g.issn.0253-9802.2014.11.014
左西孟旦在心脏外科重症患者术后早期的应用体会
Experiences with application of levosimendan in cardiac surgical patients during early postoperative stage
王翠苹 1杨嵩 1张宝 1张文波 1李华明 1唐白云1
作者信息
- 1. 510080 广州，中山大学附属第一医院心脏外科ICU
- 折叠
摘要
Abstract
Objective To explore the application significance of levosimendan in early stage after the open heart surgery in critical patients. Methods Eighty-eight critical patients who presented with acute cardi-ac dysfunction after cardiac surgery and were treated with levosimendan. The changes in dosage of vasoactive drugs,hemodynamics,proBNP and LVEF were analyzed before and after use of levosimendan. Results The doses of dopamine and norepinephrine at 8 h after use of levosimendan were lower than those before levosimen-dan(P<0.05 ). The dosages of dopamine and norepinephrine at 24 h later were significantly higher compared with those prior to use of levosimendan (P<0.05 ). At 8 h after use of levosimendan,the doses of dobutamine and adrenaline began to decrease and even remain unchanged,significantly differing from the levels before use of levosimendan. The systolic blood pressure(SBP)and heart rate(HR)did not significantly change,whereas central venous pressure(CVP)and lactic acid (Lac)had a declining trend. CVP significantly changed at 24 h after use of levosimendan(P<0.05 ). Lac significantly differed at 24 h following use of levosimendan. Urine volume began to significantly increase at 8 h after use of levosimendan(P<0.05 ). The levels of LVEF were significantly elevated at 24 h,3 d and 1 week after using levosimendan(all P<0.01 ). The level of proBNP gradually declined and significantly differed at 3 d after use of levosimendan (P<0.05 ). Conclusions Ap-plication of evosimendan after open heart surgery can reduce the dosage of vasoactive drugs,maintain the stabil-ity of hemodynamics and effectively improve heart function in critical patients.关键词
左西孟旦/心脏外科/急性心功能不全/术后Key words
Levosimendan/Cardiac surgery/Acute cardiac dysfunction/Postoperative引用本文复制引用
王翠苹,杨嵩,张宝,张文波,李华明,唐白云..左西孟旦在心脏外科重症患者术后早期的应用体会[J].新医学,2014,(11):758-762,5.
