新医学Issue(12)：808-811,4.DOI:10.3969/g.issn.0253-9802.2014.12.006
内镜下高频电凝加PPI治疗短段Barrett食管的临床研究
Clinical efficacy of endoscopic high-frequency electrocoagulation combined with PPI in treatment of short-segment Barrett's esophagus
摘要
Abstract
Objective To study the clinical efficacy of endoscopic high-frequency electrocoagulation combined with proton pump inhibitor (PPI)in the treatment of tongue-and island-type SSBE. Methods Sixty patients pathologically diagnosed with tongue-and island-type SSBE were divided into the treatment (n=30 ) and control groups (n =30 ). In the treatment group,patients were treated with endoscopic high-frequency electrocoagulation combined with 20 mg of rabeprazole twice daily for 4 consecutive weeks,while the counter-parts in the control group were treated with 20 mg of rabeprazole twice daily for 4 consecutive weeks,and the dose was reduced to 20 mg of rabeprazole once daily and the maintenance therapy was delivered for 1 year. All patients underwent gastroscopy and biopsy samples were collected for pathological examination at 3,6,12,18 and 24 months after treatment beginning. The patients in the treatment group achieved no significant efficacy repeatedly received endoscopic high-frequency electrocoagulation and rabeprazole administration for another 4 weeks. Results In the treatment group,average significant efficacious rate was 87. 0% and total efficacious rate was 100%,significantly higher compared with 8. 1% and 27. 8% in the control group (both P<0. 01 ). No postoperative complications,such as bleeding,perforation,esophagostenosis were observed in the treatment group. Conclusions Endoscopic high-frequency electrocoagulation combined with PPI is an efficacious and safe treatment of SSBE,and yields few complications.关键词
Barrett食管,短段/高频电凝术/质子泵抑制剂/临床疗效Key words
Barrett's esophagus,short-segment/High-frequency electrocoagulation/Proton pump in-hibitor/Clinical efficacy引用本文复制引用
何远琴,侯俊,李静娴,赖敏莉..内镜下高频电凝加PPI治疗短段Barrett食管的临床研究[J].新医学,2014,(12):808-811,4.基金项目
广东省佛山市卫生局医学科研计划资助 （）
