新医学Issue(12)：828-831,4.DOI:10.3969/g.issn.0253-9802.2014.12.011
肠道病毒71型感染重症患儿血浆内皮素-1及TN F-α水平的研究
Analysis of plasma ET-1 and TNF-αin children with severe HFMD infected with EV71
摘要
Abstract
Objective To assess the plasma levels of endothelin-1 (ET-1 )and tumor necrosis factor (TNF-α)in peripheral blood of children with severe hand,foot and mouth disease (HFMD)infected with EV71,aiming to explore the clinical significance of these changes in HFMD children infected with EV71. Methods The children who were diagnosed with severe HFMD and EV7 1 infection hospitalized were enrolled in this study. Thirty children diagnosed with stage II HFMD,30 stage III HFMD and 16 stage IV HFDM were assigned into study groups 1 ,2 and 3. Thirty HFMD children were allocated into the normal control group and 30 into the healthy control group. The blood samples were collected during the acute,remission and recovery stages among all groups. The plasma concentration of ET-1 and TNF-αwas detected by using ELISA. Results The changes in the plasma concentration of ET-1 were not significant in study group 1 ,which did not signifi-cantly differ from those in the healthy control group (P>0. 05 ). The plasma concentration of ET-1 in study groups 2 and 3 was significantly higher than that in the healthy control group during the acute stage,which in-creased along with the deterioration of diseases (P<0. 05 ). Along with the gradual recovery,the plasma levels of ET-1 in study groups 2 and 3 declined to normal level,significantly differing from that during the acute stage (P<0. 05 ). The plasma concentration of TNF-αin all study groups were significantly higher than that in the control group during the acute phase,and tended to elevate along with the worsening of clinical stage with sta-tistical significance (P<0. 05 ). Over the period of recovery,the changes in plasma concentration of TNF-αwere not significant in the study groups 1 and 2 (P>0. 05 ). The level of TNF-αin study group 3 gradually de-clined to normal level,significantly differing from that during the acute stage (P<0. 05 ). The plasma levels of TNF-αand ET-1 did not significantly differ between the normal and healthy control groups. Conclusions TNF-αand ET-1 might be involved with the underlying mechanism of HFMD damages combined with EV7 1 in-fection. The changes in the peripheral blood concentration of TNF-αand ET-1 can reflect the development of diseases and evaluation of clinical efficacy.关键词
手足口病/肠道病毒/内皮素-1/肿瘤坏死因子-αKey words
Hand,foot and mouth disease/Human enterovirus 7 1/Tumor necrosis factor-α/Endothelin-1引用本文复制引用
柴鸣荣,邸晓华,袁海超,黄振华,王丽婵,曾伟斌..肠道病毒71型感染重症患儿血浆内皮素-1及TN F-α水平的研究[J].新医学,2014,(12):828-831,4.基金项目
东莞市科技计划重点项目 （）
