新医学Issue(3)：183-186,4.DOI:10.3969/g.issn.0253-9802.2015.03.012
5-氨基酮戊酸光动力疗法联合二氧化碳激光治疗尖锐湿疣疗效观察
Clinical efficacy of 5-aminolevulinic acid photodynamic therapy combined with CO2 laser in the treat-ment of genital condylomata acumunata
朱建平 1刘传真 1刘永生1
作者信息
- 1. 100012 北京，中国医科大学航空总医院皮肤科
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy of combined therapy of topical 5-aminolaevu-linic acid (ALA)photodynamic therapy (PDT)and carbon dioxide laser (CO2 laser)in the treatment of con-dylomata acuminate (CA).Methods In total,1 1 7 cases diagnosed with CA were randomly divided into groups A and B.In group A,the patients were treated with CO2 laser.Those in group B underwent ALA-PDT in combination with CO2 laser.Clinical efficacy and adverse reaction were observed in both groups.All patients were followed up at 1 ,4,8,1 2 and 24 weeks after the final treatment to evaluate the recurrence rate.Results Among 1 1 7 patients,1 06 completed the treatment and subsequent follow-up.The recovery rate in group A was 72.55% (37 /51 )and 94.55% (52 /55)in group B with statistical significance (χ2 =9.508,P =0.002).The recurrence rate in group A was 37.84% (1 4 /37)and 5.77% (3 /52)in group B with statistical signifi-cance (χ2 =1 4.387,P <0.001 ).Patients in both groups presented with topical ulcer complicated with ero-sion,exudates and pain after CO2 laser therapy,which were alleviated at subsequent 1 to 2 weeks.The main adverse events in group B included local swelling,pain and erosion,which were healed at 1 to 5 days.Con-clusion The clinical efficacy of combined treatment of ALA-PDT and CO2 laser is significantly higher com-pared with that of CO2 laser in treating CA.关键词
尖锐湿疣/氨基酮戊酸/光化学疗法/二氧化碳激光Key words
Condyloma acuminata/Aminolevulinic acid/Photochemotherapy/CO2 laser引用本文复制引用
朱建平,刘传真,刘永生..5-氨基酮戊酸光动力疗法联合二氧化碳激光治疗尖锐湿疣疗效观察[J].新医学,2015,(3):183-186,4.
