新医学Issue(3)：196-201,6.DOI:10.3969/g.issn.0253-9802.2015.03.015
儿童系统性红斑狼疮合并侵袭性肺真菌病二例
Childhood-onset systemic lupus erythematosus complicated with invasive pulmonary fungal disease:two case reports
欧榕琼 1檀卫平 1董红1
作者信息
- 1. 510120 广州，中山大学孙逸仙纪念医院儿科
- 折叠
摘要
Abstract
Systemic lupus erythematosus (SLE)is a chronic autoimmune disease involvement with multiple systems.Childhood-onset SLE (cSLE)is more aggressive than adult counterparts and has a higher in-cidence of involvement with major organs,which should be administered with more potent immunosuppressants.Invasive fungal disease (IFD),especially invasive pulmonary fungal disease (IPFD),becomes one of the ma-jor causes of mortality during the treatment of cSLE due to autoimmune functional defects and use of immuno-suppressants.In this report,the clinical features of two children diagnosed as cSLE complicated with IPFD based upon the 2009 SLICC classification criteria for SLE were retrospectively studied and related literatures were reviewed.Main clinical manifestations included fever,cough and tachypnea,etc.Both patients were clin-ically diagnosed with IPFD based on sputum culture,G test and pulmonary CT.The symptoms of IPFD were al-leviated by active SLE treatment combined with empirical antifungal therapy.The diagnosis and treatment of these two cases prompted that SLE is likely to be complicated with IPFD.The diagnosis could be confirmed by sputum culture,G test and pulmonary CT,etc.After the diagnosis is confirmed,empirical or emergent anti-fungal therapy should be delivered as early as possible.Active measures should be taken to control the activity of SLE,thereby enhancing the success rate of rescuing severe cases.A sufficient course of antifungal treatment could reduce the recurrence rate of fungal infection.关键词
儿童/系统性红斑狼疮/侵袭性肺真菌病/抗真菌治疗Key words
Children/Systemic lupus erythematosus/Invasive pulmonary fungal disease/Antifungal therapy引用本文复制引用
欧榕琼,檀卫平,董红..儿童系统性红斑狼疮合并侵袭性肺真菌病二例[J].新医学,2015,(3):196-201,6.
