新医学Issue(4)：205-211,7.DOI:10.3969/g.issn.0253-9802.2015.04.001
儿童恶性血液病合并侵袭性真菌病的诊断和治疗进展
Research progress in the diagnosis and treatment of invasive fungal disease in the children with hemato-logic malignancies
邱坤银 1周敦华2
作者信息
- 1. 510120 广州，中山大学孙逸仙纪念医院儿科
- 2. 中山大学儿科学
- 折叠
摘要
Abstract
Recently,the long-term survival rate of children with hematologic malignancies has been significantly improved due to the intense and effective chemotherapy and hematopoietic stem cell transplanta-tion.The children with hematological malignancies undergoing chemotherapy are susceptible to suffering from invasive fungal diseases (IFD).However,the diagnosis and treatment of IFD have certain limitations.Hence, the incidence and mortality of hematologic malignancies complicated with IFD have been dramatically in-creased,which is becoming one of the challenging issues to clinicians.In this paper,the diagnosis and treat-ment of hematologic malignancies complicated with IFD in children were reviewed.The diagnosis of IFD includ-ed evaluation of pathogen morphology,serological and molecular biological detection,histopathological exami-nation and relevant imaging analysis.The treatment of IFD mainly consisted of preventive-,empirical-,diagno-sis-driven-and targeted-therapy.Adjuvant immunotherapy is widely employed for children with refractory or high-risk hematologic malignancies.关键词
儿童/恶性血液病/侵袭性真菌病/诊断/治疗Key words
Children/Hematologic malignancies/Invasive fungal disease/Diagnosis/Treatment引用本文复制引用
邱坤银,周敦华..儿童恶性血液病合并侵袭性真菌病的诊断和治疗进展[J].新医学,2015,(4):205-211,7.
