新医学Issue(4)：236-239,4.DOI:10.3969/g.issn.0253-9802.2015.04.007
雌激素受体、孕激素受体和细胞增殖核抗原在绝经前子宫内膜息肉中的表达及其临床意义
Expression and clinical significance of ER,PR and Ki-67 in the endometrial polyps of premenopausal women
摘要
Abstract
Objective To study the expression level and clinical significance of estrogen receptor (ER),progesterone receptor (PR)and proliferating cell nuclear antigen Ki-67 in the endometrial polyps (EP)and adjacent normal endometrial tissues from premenopausal women.Method The EP and adjacent normal endometrial tissues were collected from 36 premenopausal patients pathologically diagnosed with EP.The expression of ER,PR and proliferating cell nuclear antigen Ki-67 in the glands and stromal cells was eval-uated by immunohistochemistry between EP and adjacent normal endometrial tissues.Results In the prolifera-tive phase,the expression levels of ER and Ki-67 in the glands of EP were significantly higher than those in ad-jacent normal endometrial tissues (both P <0.05).In the secretory phase,the expression of ER in the glands of EP was significantly higher whereas that of PR was significantly lower than those in adjacent normal endome-trial tissues (both P <0.05).The expression of ER in the glands of EP was positively correlated with that of Ki-67 (P <0.05).However,the expression between ER and PR,PR and Ki-67 was not correlated in adjacent normal endometrial tissues (all P >0.05).Conclusions In the glands of EP of premenopausal patients,ER was highly expressed.In the secretory phase,PR was lowly expressed.The expression of Ki-67 and ER was positively correlated in the glands of EP.ER plays a pivotal role in the incidence,development and regulation of EP probably via promoting the proliferation of endometrial cells.关键词
雌激素受体/孕激素受体/细胞增殖核抗原/子宫内膜息肉/子宫内膜Key words
Estrogen receptor/Progesterone receptor/Ki-67/Endometrial polyps/Endometrium引用本文复制引用
封意兰,谌小卫..雌激素受体、孕激素受体和细胞增殖核抗原在绝经前子宫内膜息肉中的表达及其临床意义[J].新医学,2015,(4):236-239,4.基金项目
广东省科技计划项目 （）
