新医学Issue(4)：254-258,5.DOI:10.3969/g.issn.0253-9802.2015.04.011
不同剂量泮托拉唑对消化性溃疡并出血高危患者胃内 pH 的影响
Effect of different doses of pantoprazole on intra-gastric pH in patients with a high risk of peptic ulcer bleeding
翟丽华 1王启仪 2沙卫红 2布小玲 2岑荣英 2李子俊 2刘婉薇2
作者信息
- 1. 515041 汕头，汕头大学医学院 广东省人民医院 广东省医学科学院
- 2. 510080广州，广东省人民医院 广东省医学科学院消化内科
- 折叠
摘要
Abstract
Objective To evaluate the effect of different doses of pantoprazole on intra-gastric pH in patients with a high risk of peptic ulcer bleeding (PUB).Methods Nineteen patients diagnosed with PUB (Forrest grading:Ib-IIb)by gastroscope were divided into the high-(n =8)and regular-dose groups(n =11).In the high dose group,eight patients were intravenously administered with pantoprazole (80 mg bolus and then continuous infusion at speed of 8 mg/h)and 11 in the regular dose group were delivered with intravenous injec-tion of pantoprazole (40 mg bolus and then continuous infusion at a speed of 4 mg/h).Intra-gastric pH in all patients was monitored for 24 h.The mean time when the intra-gastric pH reached 6.0 (within 24 h)and the percentage of patients with intra-gastric pH >6.0 were observed.Results The general data including age, gender,helicobacter pylori infection,type of ulcer and endoscopic classification,etc.did not significantly dif-fer between two groups (all P >0.05).The mean time when intra-gastric pH reached 6.0 was approximately (30.50 ±4.84)min in the high dose group,which was significantly shorter than (57.09 ±13.56)min in the regular dose group (P <0.01).The percentage of patients with intra-gastric pH >6.0 in the high dose group was 95.42% (44.36%),significantly higher compared with 42.15% (40.14%)in the regular dose group (P =0.006).Conclusions Intravenous administration of pantoprazole at a high and regular dose can both in-crease intra-gastric pH to above 6 in patients with a high risk of PUB,whereas a high dose of pantoprazole yields faster and longer effect compared with a regular dosage.关键词
消化性溃疡出血/泮托拉唑/胃内pHKey words
Peptic ulcer bleeding/Pantoprazole/Intra-gastric pH引用本文复制引用
翟丽华,王启仪,沙卫红,布小玲,岑荣英,李子俊,刘婉薇..不同剂量泮托拉唑对消化性溃疡并出血高危患者胃内 pH 的影响[J].新医学,2015,(4):254-258,5.
