新医学Issue(4)：262-267,6.DOI:10.3969/g.issn.0253-9802.2015.04.013
早期糖尿病肾病患者血清尿酸水平与肾小球滤过率的相关性研究
Correlation between serum uric acid and glomerular filtration rate in T2DM patients with early stages of diabetic kidney disease
张莉 1朱翠颜 1王筱菁 1邢晓欢 1黎雅清 1林健才1
作者信息
- 1. 529030 江门，中山大学附属江门医院 江门市中心医院
- 折叠
摘要
Abstract
Objective To analyze the relationship between serum uric acid (SUA)and estimated glomerular filtration rate (eGFR)in type 2 diabetes mellitus (T2DM)patients with stages 1-3 of diabetic kid-ney disease (DKD)and evaluate the diagnostic value of SUA in early DKD.Methods In total,231 T2DM patients complicated with DKD were assigned into group A and 228 healthy controls in group B.All participants presented with eGFR ≥ 30 ml/(min·1.73 m2 ).Patients in group A were sub-grouped into A1 (stage DKD-1,n =96),A2 (stage DKD-2,n =101)and A3 (stage DKD-3,n =42)groups according to DKD stag-ing.The SUA levels were statistically compared and the correlation between SUA and eGFR was analyzed among different groups and sub-groups.Results eGFR did not significantly differ between groups A and B (P>0.05),whereas SUA level in group A was significantly higher compared with that in group B (P <0.01).The SUA levels significantly differed among subgroups A1,A2 and A3 (P <0.05)and were elevated along with DKD staging (P <0.05).In both groups A and B,SUA level was significantly correlated with eGFR (both P <0.01).Multiple linear regression analysis revealed that SUA was a risk factor for eGFR impairment in DKD patients (P <0.01).Conclusions SUA is related to the abnormity of eGFR during early DKD and acts as one of the independent risk factors,prompting that SUA probably participates in the incidence and de-velopment of renal damage during early stage of DKD.关键词
2型糖尿病/糖尿病肾病/血清尿酸/肾小球滤过率Key words
Type 2 diabetes mellitus/Diabetic kidney disease/Serum uric acid/eGFR引用本文复制引用
张莉,朱翠颜,王筱菁,邢晓欢,黎雅清,林健才..早期糖尿病肾病患者血清尿酸水平与肾小球滤过率的相关性研究[J].新医学,2015,(4):262-267,6.
