新医学Issue(6)：403-409,7.DOI:10.3969/g.issn.0253-9802.2015.06.014
Castleman 病一例并文献复习
Castleman's disease:one case report and literature review
赵银英 1周宇麒 2冯定云 2杨海玲 2刘翠婷2
作者信息
- 1. 511480 广州，广州市南沙区榄核医院
- 2. 510630 广州，中山大学附属第三医院呼吸内科
- 折叠
摘要
Abstract
Objective To enhance the understanding of clinical manifestations and treatment of Castleman's disease.Methods One typical case of Castleman's disease was reported and relevant literature was reviewed by searching the keyword “Castleman's disease”in Wanfang Data.Clinical manifestations,path-ological and therapeutic characteristics of Castleman's disease were analyzed.Results A 45 year old male was admitted because of dry cough for 2 years and chest distress for 6 months.After hospitalization,chest CT re-vealed bilateral pulmonary pathological changes in diffuse grid pattern and multiple lymph node enlargement in the mediastinum,bilateral hilar and axillary,considered as diffuse pulmonary interstitial fibrosis.Axillary lymph node biopsy was performed to confirm the final diagnosis of Castleman's disease.The symptoms were al-leviated after chemotherapy.A total of 200 cases of Castleman's disease were searched from Wanfang Data with a male to female ratio of 1 .27:1 of all ages.Among them,85 were diagnosed with multicentric Castleman's disease,1 1 5 with unicentric type,1 3 misdiagnosed cases and 51 with other complications.Among 1 87 receiv-ing treatment,85 underwent surgery,58 received chemotherapy,1 2 underwent combined therapy of surgery and chemotherapy,1 0 were treated with glucocorticoid hormone therapy and 22 with alternative treatment.In total,1 66 patients were followed up,89 were healed,61 were alleviated,1 2 had low clinical efficacy and 4 died.Conclusions Castleman's disease was characterized with no specific clinical manifestations.It was mainly manifested with typical histopathological features.It was easily to miss the diagnosis or make a misdiag-nosis.The final diagnosis should be confirmed by clinical and pathological manifestations.Castleman's disease could be alleviated by chemotherapy.关键词
Castleman病/临床表现/病理/误诊Key words
Castleman's disease/Clinical manifestation/Pathology/Misdiagnosis引用本文复制引用
赵银英,周宇麒,冯定云,杨海玲,刘翠婷..Castleman 病一例并文献复习[J].新医学,2015,(6):403-409,7.
