临床医学工程Issue(7)：853-854,2.DOI:10.3969/j.issn.1674-4659.2014.07.0853
孕妇血清IgG亚类检测对早期诊断新生儿ABO溶血性疾病的临床价值
Clinical Value of Maternal Serum IgG Subclasses Testing on the Newborn Early Diagnosis of ABO Hemolytic Disease
摘要
Abstract
Objective Objective To investigate the early diagnostic value of serum IgG subclasses testing on ABO hemolytic disease of the newborn(HDN). Methods Pregnant women with blood type O (husband with non O blood type) in our hospital from August 2011 to June 2013 for regular check ups and delivery were included. 30 cases of pregnant women with HDN after delivery were set as the experimental group and women without HDN at the same time as the control group.Relevance of IgG anti A (B) titer of pregnant women with ABO haemolytic disease of the newborn was analyzed and IgG subclass content between the experimental group and the control group was compared. Results The incidence of neonatal ABO hemolytic disease increased with IgG anti A (B) titres increased , and the difference was significant (P <0.05); IgG1, IgG3, IgG4 of .pregnant women and children in the experimental group were compared and there were statistically significant difference between groups (P <0.05). IgG2 of pregnant women in the control group and experimental group had significant difference (P<0.05);and there were significantly differences in IgG1, IgG3, IgG4 groups of pregnant women in control group(P<0.05). Conclusions The incidence of neonatal ABO hemolytic disease increased with the increase of IgG antibody titers. Pregnant women with O blood type contributed to incompatible blood type between couples should be detected early in IgG antibody titer and IgG subclass content for early detection, diagnosis and treatment, and prognosis improvement.关键词
孕妇血清IgG亚类检测/新生儿/ABO溶血性疾病/诊断价值Key words
Maternal serum IgG subclasses testing/Newborn/Neonatal ABO hemolytic disease/Diagnostic value分类
医药卫生引用本文复制引用
张少丰,余洁玲,陈楚填,李文忠,叶长钦..孕妇血清IgG亚类检测对早期诊断新生儿ABO溶血性疾病的临床价值[J].临床医学工程,2014,(7):853-854,2.基金项目
东莞市科技局科研立项课题 （）
